Abstract
Intrinsic regulators of the pluripotency of mouse ES (embryonic stem) cells include the homeodomain proteins Oct4 and the recently identified Nanog. When overexpressed, Nanog displays the unique attribute of robustly sustaining ES cell self-renewal in the absence of the otherwise requisite extracellular stimulation by LIF (leukaemia inhibitory factor) and BMP (bone morphogenetic protein). Here, we review our current understanding of the function of Nanog in pluripotent stem cells both in vitro and in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 1518-1521 |
| Number of pages | 4 |
| Journal | Biochemical Society Transactions |
| Volume | 33 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2005 |
| Externally published | Yes |