The imidazole catalysed hydrolysis of triacetin: An inter- and intra-laboratory development of a test reaction for isothermal heat conduction microcalorimeters used for determination of both thermodynamic and kinetic parameters

Anthony E. Beezer, Andrew K. Hills, Michael A.A. O'Neill, Andrew C. Morris, Katharine T.E. Kierstan, Rebecca M. Deal, Laura J. Waters, Jonathan Hadgraft, John C. Mitchell, Joseph A. Connor, John E. Orchard, Richard J. Willson, Thomas C. Hofelich, Jennifer Beaudin, Gert Wolf, Felix Baitalow, Simon Gaisford, Roy A. Lane, Graham Buckton, Mark A. Phipps & 5 others Richard A. Winneke, Eric A. Schmitt, Lee D. Hansen, David O'Sullivan, Madhu K. Parmar

Research output: Contribution to journalArticle

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Abstract

This paper reports the outcomes of an inter- and intra-laboratory microcalorimetric investigation of the triacetin hydrolysis reaction in an imidazole/acetic acid buffer system. The purpose was to establish whether this reaction would be an appropriate test reaction system for validation of isothermal heat conduction microcalorimeters used to determine both thermodynamic and kinetic data. To be acceptable for this purpose a reaction should be simple to perform, robust in operation, undemanding with respect to sources of chemicals, operators, calorimeters and their operating procedures (within defined limits). The reaction system studied is shown to fulfil these criteria. For this second-order reaction, performed at 298 K the recommended values for the reaction rate constant, k, and the enthalpy change, ΔRH, are: k = 2.80 ± 0.10 × 10-6 dm3 mol-1 s-1; ΔRH = -91.7 ± 3.0 kJ mol-1.

LanguageEnglish
Pages13-17
Number of pages5
JournalThermochimica Acta
Volume380
Issue number1
Early online date6 Nov 2001
DOIs
Publication statusPublished - 30 Nov 2001
Externally publishedYes

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Triacetin
triacetin
imidazoles
Kinetic parameters
Heat conduction
conductive heat transfer
calorimeters
hydrolysis
Hydrolysis
Thermodynamics
thermodynamics
kinetics
Calorimeters
Acetic acid
Acetic Acid
Reaction rates
Enthalpy
Rate constants
Buffers
Kinetics

Cite this

Beezer, Anthony E. ; Hills, Andrew K. ; O'Neill, Michael A.A. ; Morris, Andrew C. ; Kierstan, Katharine T.E. ; Deal, Rebecca M. ; Waters, Laura J. ; Hadgraft, Jonathan ; Mitchell, John C. ; Connor, Joseph A. ; Orchard, John E. ; Willson, Richard J. ; Hofelich, Thomas C. ; Beaudin, Jennifer ; Wolf, Gert ; Baitalow, Felix ; Gaisford, Simon ; Lane, Roy A. ; Buckton, Graham ; Phipps, Mark A. ; Winneke, Richard A. ; Schmitt, Eric A. ; Hansen, Lee D. ; O'Sullivan, David ; Parmar, Madhu K. / The imidazole catalysed hydrolysis of triacetin : An inter- and intra-laboratory development of a test reaction for isothermal heat conduction microcalorimeters used for determination of both thermodynamic and kinetic parameters. In: Thermochimica Acta. 2001 ; Vol. 380, No. 1. pp. 13-17.
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title = "The imidazole catalysed hydrolysis of triacetin: An inter- and intra-laboratory development of a test reaction for isothermal heat conduction microcalorimeters used for determination of both thermodynamic and kinetic parameters",
abstract = "This paper reports the outcomes of an inter- and intra-laboratory microcalorimetric investigation of the triacetin hydrolysis reaction in an imidazole/acetic acid buffer system. The purpose was to establish whether this reaction would be an appropriate test reaction system for validation of isothermal heat conduction microcalorimeters used to determine both thermodynamic and kinetic data. To be acceptable for this purpose a reaction should be simple to perform, robust in operation, undemanding with respect to sources of chemicals, operators, calorimeters and their operating procedures (within defined limits). The reaction system studied is shown to fulfil these criteria. For this second-order reaction, performed at 298 K the recommended values for the reaction rate constant, k, and the enthalpy change, ΔRH, are: k = 2.80 ± 0.10 × 10-6 dm3 mol-1 s-1; ΔRH = -91.7 ± 3.0 kJ mol-1.",
keywords = "Kinetics, Microcalorimetry, Test reaction, Thermodynamics, Triacetin",
author = "Beezer, {Anthony E.} and Hills, {Andrew K.} and O'Neill, {Michael A.A.} and Morris, {Andrew C.} and Kierstan, {Katharine T.E.} and Deal, {Rebecca M.} and Waters, {Laura J.} and Jonathan Hadgraft and Mitchell, {John C.} and Connor, {Joseph A.} and Orchard, {John E.} and Willson, {Richard J.} and Hofelich, {Thomas C.} and Jennifer Beaudin and Gert Wolf and Felix Baitalow and Simon Gaisford and Lane, {Roy A.} and Graham Buckton and Phipps, {Mark A.} and Winneke, {Richard A.} and Schmitt, {Eric A.} and Hansen, {Lee D.} and David O'Sullivan and Parmar, {Madhu K.}",
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Beezer, AE, Hills, AK, O'Neill, MAA, Morris, AC, Kierstan, KTE, Deal, RM, Waters, LJ, Hadgraft, J, Mitchell, JC, Connor, JA, Orchard, JE, Willson, RJ, Hofelich, TC, Beaudin, J, Wolf, G, Baitalow, F, Gaisford, S, Lane, RA, Buckton, G, Phipps, MA, Winneke, RA, Schmitt, EA, Hansen, LD, O'Sullivan, D & Parmar, MK 2001, 'The imidazole catalysed hydrolysis of triacetin: An inter- and intra-laboratory development of a test reaction for isothermal heat conduction microcalorimeters used for determination of both thermodynamic and kinetic parameters', Thermochimica Acta, vol. 380, no. 1, pp. 13-17. https://doi.org/10.1016/S0040-6031(01)00629-3

The imidazole catalysed hydrolysis of triacetin : An inter- and intra-laboratory development of a test reaction for isothermal heat conduction microcalorimeters used for determination of both thermodynamic and kinetic parameters. / Beezer, Anthony E.; Hills, Andrew K.; O'Neill, Michael A.A.; Morris, Andrew C.; Kierstan, Katharine T.E.; Deal, Rebecca M.; Waters, Laura J.; Hadgraft, Jonathan; Mitchell, John C.; Connor, Joseph A.; Orchard, John E.; Willson, Richard J.; Hofelich, Thomas C.; Beaudin, Jennifer; Wolf, Gert; Baitalow, Felix; Gaisford, Simon; Lane, Roy A.; Buckton, Graham; Phipps, Mark A.; Winneke, Richard A.; Schmitt, Eric A.; Hansen, Lee D.; O'Sullivan, David; Parmar, Madhu K.

In: Thermochimica Acta, Vol. 380, No. 1, 30.11.2001, p. 13-17.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The imidazole catalysed hydrolysis of triacetin

T2 - Thermochimica Acta

AU - Beezer, Anthony E.

AU - Hills, Andrew K.

AU - O'Neill, Michael A.A.

AU - Morris, Andrew C.

AU - Kierstan, Katharine T.E.

AU - Deal, Rebecca M.

AU - Waters, Laura J.

AU - Hadgraft, Jonathan

AU - Mitchell, John C.

AU - Connor, Joseph A.

AU - Orchard, John E.

AU - Willson, Richard J.

AU - Hofelich, Thomas C.

AU - Beaudin, Jennifer

AU - Wolf, Gert

AU - Baitalow, Felix

AU - Gaisford, Simon

AU - Lane, Roy A.

AU - Buckton, Graham

AU - Phipps, Mark A.

AU - Winneke, Richard A.

AU - Schmitt, Eric A.

AU - Hansen, Lee D.

AU - O'Sullivan, David

AU - Parmar, Madhu K.

PY - 2001/11/30

Y1 - 2001/11/30

N2 - This paper reports the outcomes of an inter- and intra-laboratory microcalorimetric investigation of the triacetin hydrolysis reaction in an imidazole/acetic acid buffer system. The purpose was to establish whether this reaction would be an appropriate test reaction system for validation of isothermal heat conduction microcalorimeters used to determine both thermodynamic and kinetic data. To be acceptable for this purpose a reaction should be simple to perform, robust in operation, undemanding with respect to sources of chemicals, operators, calorimeters and their operating procedures (within defined limits). The reaction system studied is shown to fulfil these criteria. For this second-order reaction, performed at 298 K the recommended values for the reaction rate constant, k, and the enthalpy change, ΔRH, are: k = 2.80 ± 0.10 × 10-6 dm3 mol-1 s-1; ΔRH = -91.7 ± 3.0 kJ mol-1.

AB - This paper reports the outcomes of an inter- and intra-laboratory microcalorimetric investigation of the triacetin hydrolysis reaction in an imidazole/acetic acid buffer system. The purpose was to establish whether this reaction would be an appropriate test reaction system for validation of isothermal heat conduction microcalorimeters used to determine both thermodynamic and kinetic data. To be acceptable for this purpose a reaction should be simple to perform, robust in operation, undemanding with respect to sources of chemicals, operators, calorimeters and their operating procedures (within defined limits). The reaction system studied is shown to fulfil these criteria. For this second-order reaction, performed at 298 K the recommended values for the reaction rate constant, k, and the enthalpy change, ΔRH, are: k = 2.80 ± 0.10 × 10-6 dm3 mol-1 s-1; ΔRH = -91.7 ± 3.0 kJ mol-1.

KW - Kinetics

KW - Microcalorimetry

KW - Test reaction

KW - Thermodynamics

KW - Triacetin

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U2 - 10.1016/S0040-6031(01)00629-3

DO - 10.1016/S0040-6031(01)00629-3

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EP - 17

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JF - Thermochimica Acta

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