The importance of genetic susceptibility in Dupuytren's disease

K. Becker, S. Tinschert, A. Lienert, P. E. Bleuler, F. Staub, A. Meinel, J. Rößler, W. Wach, R. Hoffmann, F. Kühnel, H. G. Damert, H. E. Nick, R. Spicher, W. Lenze, M. Langer, P. Nürnberg, H. C. Hennies

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Dupuytren's disease (DD) is a progressive fibromatosis that causes the formation of nodules and cords in the palmar aponeurosis leading to flexion contracture of affected fingers. The etiopathogenesis is multifactorial with a strong genetic predisposition. It is the most frequent genetic disorder of connective tissues. We have collected clinical data from 736 unrelated individuals with DD who underwent surgical treatment from Germany and Switzerland. We evaluated a standardised questionnaire, assessed the importance of different risk factors and compared subgroups with and without positive family history. We found that family history clearly had the strongest influence on the age at first surgery compared to environmental factors, followed by male sex. Participants with a positive family history were on average 55.9years of age at the first surgical intervention, 5.2years younger than probands without known family history (p=6.7×10-8). The percentage of familial cases decreased with age of onset from 55% in the 40-49 years old to 17% at age 80years or older. Further risk factors analysed were cigarettes, alcohol, diabetes, hypertension, and epilepsy. Our data pinpoint the importance of genetic susceptibility for DD, which has long been underestimated.

LanguageEnglish
Pages483-487
Number of pages5
JournalClinical Genetics
Volume87
Issue number5
Early online date15 May 2014
DOIs
Publication statusPublished - May 2015
Externally publishedYes

Fingerprint

Dupuytren Contracture
Genetic Predisposition to Disease
Inborn Genetic Diseases
Fibroma
Contracture
Switzerland
Age of Onset
Tobacco Products
Connective Tissue
Fingers
Germany
Epilepsy
Alcohols
Hypertension

Cite this

Becker, K., Tinschert, S., Lienert, A., Bleuler, P. E., Staub, F., Meinel, A., ... Hennies, H. C. (2015). The importance of genetic susceptibility in Dupuytren's disease. Clinical Genetics, 87(5), 483-487. https://doi.org/10.1111/cge.12410
Becker, K. ; Tinschert, S. ; Lienert, A. ; Bleuler, P. E. ; Staub, F. ; Meinel, A. ; Rößler, J. ; Wach, W. ; Hoffmann, R. ; Kühnel, F. ; Damert, H. G. ; Nick, H. E. ; Spicher, R. ; Lenze, W. ; Langer, M. ; Nürnberg, P. ; Hennies, H. C. / The importance of genetic susceptibility in Dupuytren's disease. In: Clinical Genetics. 2015 ; Vol. 87, No. 5. pp. 483-487.
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Becker, K, Tinschert, S, Lienert, A, Bleuler, PE, Staub, F, Meinel, A, Rößler, J, Wach, W, Hoffmann, R, Kühnel, F, Damert, HG, Nick, HE, Spicher, R, Lenze, W, Langer, M, Nürnberg, P & Hennies, HC 2015, 'The importance of genetic susceptibility in Dupuytren's disease', Clinical Genetics, vol. 87, no. 5, pp. 483-487. https://doi.org/10.1111/cge.12410

The importance of genetic susceptibility in Dupuytren's disease. / Becker, K.; Tinschert, S.; Lienert, A.; Bleuler, P. E.; Staub, F.; Meinel, A.; Rößler, J.; Wach, W.; Hoffmann, R.; Kühnel, F.; Damert, H. G.; Nick, H. E.; Spicher, R.; Lenze, W.; Langer, M.; Nürnberg, P.; Hennies, H. C.

In: Clinical Genetics, Vol. 87, No. 5, 05.2015, p. 483-487.

Research output: Contribution to journalArticle

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T1 - The importance of genetic susceptibility in Dupuytren's disease

AU - Becker, K.

AU - Tinschert, S.

AU - Lienert, A.

AU - Bleuler, P. E.

AU - Staub, F.

AU - Meinel, A.

AU - Rößler, J.

AU - Wach, W.

AU - Hoffmann, R.

AU - Kühnel, F.

AU - Damert, H. G.

AU - Nick, H. E.

AU - Spicher, R.

AU - Lenze, W.

AU - Langer, M.

AU - Nürnberg, P.

AU - Hennies, H. C.

N1 - No full text in Eprints. HN 14/11/2017

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Y1 - 2015/5

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KW - Dupuytren's diathesis

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KW - Myofibroblast

KW - Risk factors

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Becker K, Tinschert S, Lienert A, Bleuler PE, Staub F, Meinel A et al. The importance of genetic susceptibility in Dupuytren's disease. Clinical Genetics. 2015 May;87(5):483-487. https://doi.org/10.1111/cge.12410