Abstract
Heparan sulfate proteoglycans (HSPGs) are complex glycoproteins present ubiquitously at the cell surface and in the extracellular matrix. Heparan sulfate (HS) and HSPGs interact with a variety of growth factors, morphogens, extracellular matrix (ECM) proteins and proteases and thus play essential roles in controlling cell differentiation, tissue morphogenesis and homeostasis. The importance of HS and HSPGs has been highlighted by the findings that a number of human genetic disorders are associated with mutations in genes encoding for HSPGs or HS biosynthetic enzymes. The HS mediated interactions are often dependent on specific HS structures that arise from differential sulfation modifications to the sugar backbone during biosynthesis. The fine structure of HS varies tissue specifically, during development and in disease conditions but the regulation of HS biosynthesis is still not fully understood. Recent studies using genetic model organisms together with cell biological and biochemical approaches have indicated specific roles for heparan sulfotransferases in defined developmental pathways emphasizing the importance of specific HS structures during development.
| Original language | English |
|---|---|
| Pages (from-to) | 185-195 |
| Number of pages | 11 |
| Journal | Trends in Glycoscience and Glycotechnology |
| Volume | 18 |
| Issue number | 101 |
| DOIs | |
| Publication status | Published - 2006 |
| Externally published | Yes |
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The importance of specific sulfate modifications in heparan sulfate functions. / Kinnunen, Tarja K.
In: Trends in Glycoscience and Glycotechnology, Vol. 18, No. 101, 2006, p. 185-195.Research output: Contribution to journal › Article
TY - JOUR
T1 - The importance of specific sulfate modifications in heparan sulfate functions
AU - Kinnunen, Tarja K.
PY - 2006
Y1 - 2006
N2 - Heparan sulfate proteoglycans (HSPGs) are complex glycoproteins present ubiquitously at the cell surface and in the extracellular matrix. Heparan sulfate (HS) and HSPGs interact with a variety of growth factors, morphogens, extracellular matrix (ECM) proteins and proteases and thus play essential roles in controlling cell differentiation, tissue morphogenesis and homeostasis. The importance of HS and HSPGs has been highlighted by the findings that a number of human genetic disorders are associated with mutations in genes encoding for HSPGs or HS biosynthetic enzymes. The HS mediated interactions are often dependent on specific HS structures that arise from differential sulfation modifications to the sugar backbone during biosynthesis. The fine structure of HS varies tissue specifically, during development and in disease conditions but the regulation of HS biosynthesis is still not fully understood. Recent studies using genetic model organisms together with cell biological and biochemical approaches have indicated specific roles for heparan sulfotransferases in defined developmental pathways emphasizing the importance of specific HS structures during development.
AB - Heparan sulfate proteoglycans (HSPGs) are complex glycoproteins present ubiquitously at the cell surface and in the extracellular matrix. Heparan sulfate (HS) and HSPGs interact with a variety of growth factors, morphogens, extracellular matrix (ECM) proteins and proteases and thus play essential roles in controlling cell differentiation, tissue morphogenesis and homeostasis. The importance of HS and HSPGs has been highlighted by the findings that a number of human genetic disorders are associated with mutations in genes encoding for HSPGs or HS biosynthetic enzymes. The HS mediated interactions are often dependent on specific HS structures that arise from differential sulfation modifications to the sugar backbone during biosynthesis. The fine structure of HS varies tissue specifically, during development and in disease conditions but the regulation of HS biosynthesis is still not fully understood. Recent studies using genetic model organisms together with cell biological and biochemical approaches have indicated specific roles for heparan sulfotransferases in defined developmental pathways emphasizing the importance of specific HS structures during development.
KW - Development
KW - Heparan sulfate
KW - Morphogens
KW - Nervous system
KW - Sulfotransferase
UR - http://www.scopus.com/inward/record.url?scp=33747112977&partnerID=8YFLogxK
U2 - 10.4052/tigg.18.185
DO - 10.4052/tigg.18.185
M3 - Article
AN - SCOPUS:33747112977
VL - 18
SP - 185
EP - 195
JO - Trends in Glycoscience and Glycotechnology
JF - Trends in Glycoscience and Glycotechnology
SN - 0915-7352
IS - 101
ER -