The importance of specific sulfate modifications in heparan sulfate functions

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Heparan sulfate proteoglycans (HSPGs) are complex glycoproteins present ubiquitously at the cell surface and in the extracellular matrix. Heparan sulfate (HS) and HSPGs interact with a variety of growth factors, morphogens, extracellular matrix (ECM) proteins and proteases and thus play essential roles in controlling cell differentiation, tissue morphogenesis and homeostasis. The importance of HS and HSPGs has been highlighted by the findings that a number of human genetic disorders are associated with mutations in genes encoding for HSPGs or HS biosynthetic enzymes. The HS mediated interactions are often dependent on specific HS structures that arise from differential sulfation modifications to the sugar backbone during biosynthesis. The fine structure of HS varies tissue specifically, during development and in disease conditions but the regulation of HS biosynthesis is still not fully understood. Recent studies using genetic model organisms together with cell biological and biochemical approaches have indicated specific roles for heparan sulfotransferases in defined developmental pathways emphasizing the importance of specific HS structures during development.

Original languageEnglish
Pages (from-to)185-195
Number of pages11
JournalTrends in Glycoscience and Glycotechnology
Volume18
Issue number101
DOIs
Publication statusPublished - 2006
Externally publishedYes

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Heparitin Sulfate
Sulfates
Heparan Sulfate Proteoglycans
Biosynthesis
Tissue
Sulfotransferases
Inborn Genetic Diseases
Gene encoding
Extracellular Matrix Proteins
Genetic Models
Medical Genetics
Morphogenesis
Sugars
Extracellular Matrix
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Glycoproteins
Homeostasis
Peptide Hydrolases
Mutation

Cite this

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title = "The importance of specific sulfate modifications in heparan sulfate functions",
abstract = "Heparan sulfate proteoglycans (HSPGs) are complex glycoproteins present ubiquitously at the cell surface and in the extracellular matrix. Heparan sulfate (HS) and HSPGs interact with a variety of growth factors, morphogens, extracellular matrix (ECM) proteins and proteases and thus play essential roles in controlling cell differentiation, tissue morphogenesis and homeostasis. The importance of HS and HSPGs has been highlighted by the findings that a number of human genetic disorders are associated with mutations in genes encoding for HSPGs or HS biosynthetic enzymes. The HS mediated interactions are often dependent on specific HS structures that arise from differential sulfation modifications to the sugar backbone during biosynthesis. The fine structure of HS varies tissue specifically, during development and in disease conditions but the regulation of HS biosynthesis is still not fully understood. Recent studies using genetic model organisms together with cell biological and biochemical approaches have indicated specific roles for heparan sulfotransferases in defined developmental pathways emphasizing the importance of specific HS structures during development.",
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The importance of specific sulfate modifications in heparan sulfate functions. / Kinnunen, Tarja K.

In: Trends in Glycoscience and Glycotechnology, Vol. 18, No. 101, 2006, p. 185-195.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The importance of specific sulfate modifications in heparan sulfate functions

AU - Kinnunen, Tarja K.

PY - 2006

Y1 - 2006

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AB - Heparan sulfate proteoglycans (HSPGs) are complex glycoproteins present ubiquitously at the cell surface and in the extracellular matrix. Heparan sulfate (HS) and HSPGs interact with a variety of growth factors, morphogens, extracellular matrix (ECM) proteins and proteases and thus play essential roles in controlling cell differentiation, tissue morphogenesis and homeostasis. The importance of HS and HSPGs has been highlighted by the findings that a number of human genetic disorders are associated with mutations in genes encoding for HSPGs or HS biosynthetic enzymes. The HS mediated interactions are often dependent on specific HS structures that arise from differential sulfation modifications to the sugar backbone during biosynthesis. The fine structure of HS varies tissue specifically, during development and in disease conditions but the regulation of HS biosynthesis is still not fully understood. Recent studies using genetic model organisms together with cell biological and biochemical approaches have indicated specific roles for heparan sulfotransferases in defined developmental pathways emphasizing the importance of specific HS structures during development.

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