The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets

Elijah I. Nep, Mohammed Mahdi, Adeola Adebisi, C. Dawson, Karl Walton, Paul Bills, Barbara Conway, Alan Smith, Kofi Asare-Addo

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3 Citations (Scopus)

Abstract

Co-administration of drugs with alcohol can affect the plasma concentration of drugs in patients. It is also known that the excipients used in the formulation of drugs may not always be resistant to alcohol. This study evaluates effect of varying alcohol concentrations on theophylline release from two grades of Grewia mollis polysaccharides. X-ray microtomography showed that native polysaccharide formulation compacts were not homogenous after the mixing process resulting in its failure in swelling studies. Removal of starch from the native polysaccharide resulted in homogenous formulation compacts resistant to damage in high alcoholic media in pH 6.8 (40%v/v absolute ethanol). Destarched polymer compacts had a significantly higher hardness (375 N) than that of the native polysaccharide (82 N) and HPMC K4 M (146 N). Dissolution studies showed similarity at all levels of alcohol tested (f2 = 57-91) in simulated gastric media (pH 1.2). The dissolution profiles in the simulated intestinal fluids were also similar (f2 = 60-94), with the exception of the native polysaccharide in pH 6.8 (40%v/v absolute ethanol) (f2 = 43). This work highlights the properties of Grewia polysaccharide as a matrix former that can resist high alcoholic effects therefore; it may be suitable as an alternative to some of the commercially available matrix formers with wider applications for drug delivery as a cheaper alternative in the developing world.
LanguageEnglish
Pages352-364
Number of pages13
JournalInternational Journal of Pharmaceutics
Volume532
Issue number1
Early online date10 Sep 2017
DOIs
Publication statusPublished - 30 Oct 2017

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Grewia
Tablets
Polysaccharides
Alcohols
Ethanol
Pharmaceutical Preparations
X-Ray Microtomography
Drug Compounding
Excipients
Hardness
Theophylline
Starch
Stomach
Polymers

Cite this

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title = "The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets",
abstract = "Co-administration of drugs with alcohol can affect the plasma concentration of drugs in patients. It is also known that the excipients used in the formulation of drugs may not always be resistant to alcohol. This study evaluates effect of varying alcohol concentrations on theophylline release from two grades of Grewia mollis polysaccharides. X-ray microtomography showed that native polysaccharide formulation compacts were not homogenous after the mixing process resulting in its failure in swelling studies. Removal of starch from the native polysaccharide resulted in homogenous formulation compacts resistant to damage in high alcoholic media in pH 6.8 (40{\%}v/v absolute ethanol). Destarched polymer compacts had a significantly higher hardness (375 N) than that of the native polysaccharide (82 N) and HPMC K4 M (146 N). Dissolution studies showed similarity at all levels of alcohol tested (f2 = 57-91) in simulated gastric media (pH 1.2). The dissolution profiles in the simulated intestinal fluids were also similar (f2 = 60-94), with the exception of the native polysaccharide in pH 6.8 (40{\%}v/v absolute ethanol) (f2 = 43). This work highlights the properties of Grewia polysaccharide as a matrix former that can resist high alcoholic effects therefore; it may be suitable as an alternative to some of the commercially available matrix formers with wider applications for drug delivery as a cheaper alternative in the developing world.",
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AU - Nep, Elijah I.

AU - Mahdi, Mohammed

AU - Adebisi, Adeola

AU - Dawson, C.

AU - Walton, Karl

AU - Bills, Paul

AU - Conway, Barbara

AU - Smith, Alan

AU - Asare-Addo, Kofi

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