The initial peopling of the Americas: A growing number of founding mitochondrial genomes from Beringia

Ugo A. Perego, Norman Angerhofer, Maria Pala, Anna Olivieri, Hovirag Lancioni, Baharak Hooshiar Kashani, Valeria Carossa, Jayne E. Ekins, Alberto Gómez-Carballa, Gabriela Huber, Bettina Zimmermann, Daniel Corach, Nora Babudri, Fausto Panara, Natalie M. Myres, Walther Parson, Ornella Semino, Antonio Salas, Scott R. Woodward, Alessandro Achilli & 1 others Antonio Torroni

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages and geographical distributions that are indicative of an early arrival from Beringia with Paleo-Indians. In contrast, the estimated ages of C1d - the third subset of C1 - looked too young to fit the above scenario. To define the origin of this enigmatic C1 branch, we completely sequenced 63 C1d mitochondrial genomes from a wide range of geographically diverse, mixed, and indigenous American populations. The revised phylogeny not only brings the age of C1d within the range of that of its two sister clades, but reveals that there were two C1d founder genomes for Paleo-Indians. Thus, the recognized maternal founding lineages of Native Americans are at least 15, indicating that the overall number of Beringian or Asian founder mitochondrial genomes will probably increase extensively when all Native American haplogroups reach the same level of phylogenetic and genomic resolution as obtained here for C1d.

LanguageEnglish
Pages1174-1179
Number of pages6
JournalGenome Research
Volume20
Issue number9
Early online date29 Jun 2010
DOIs
Publication statusPublished - 1 Sep 2010
Externally publishedYes

Fingerprint

Mitochondrial Genome
North American Indians
Age Distribution
Phylogeny
Mitochondrial DNA
Population Groups
Siblings
Mothers
Genome

Cite this

Perego, U. A., Angerhofer, N., Pala, M., Olivieri, A., Lancioni, H., Kashani, B. H., ... Torroni, A. (2010). The initial peopling of the Americas: A growing number of founding mitochondrial genomes from Beringia. Genome Research, 20(9), 1174-1179. https://doi.org/10.1101/gr.109231.110
Perego, Ugo A. ; Angerhofer, Norman ; Pala, Maria ; Olivieri, Anna ; Lancioni, Hovirag ; Kashani, Baharak Hooshiar ; Carossa, Valeria ; Ekins, Jayne E. ; Gómez-Carballa, Alberto ; Huber, Gabriela ; Zimmermann, Bettina ; Corach, Daniel ; Babudri, Nora ; Panara, Fausto ; Myres, Natalie M. ; Parson, Walther ; Semino, Ornella ; Salas, Antonio ; Woodward, Scott R. ; Achilli, Alessandro ; Torroni, Antonio. / The initial peopling of the Americas : A growing number of founding mitochondrial genomes from Beringia. In: Genome Research. 2010 ; Vol. 20, No. 9. pp. 1174-1179.
@article{e58da05cf65a4334b28a61c3be89fb2d,
title = "The initial peopling of the Americas: A growing number of founding mitochondrial genomes from Beringia",
abstract = "Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages and geographical distributions that are indicative of an early arrival from Beringia with Paleo-Indians. In contrast, the estimated ages of C1d - the third subset of C1 - looked too young to fit the above scenario. To define the origin of this enigmatic C1 branch, we completely sequenced 63 C1d mitochondrial genomes from a wide range of geographically diverse, mixed, and indigenous American populations. The revised phylogeny not only brings the age of C1d within the range of that of its two sister clades, but reveals that there were two C1d founder genomes for Paleo-Indians. Thus, the recognized maternal founding lineages of Native Americans are at least 15, indicating that the overall number of Beringian or Asian founder mitochondrial genomes will probably increase extensively when all Native American haplogroups reach the same level of phylogenetic and genomic resolution as obtained here for C1d.",
author = "Perego, {Ugo A.} and Norman Angerhofer and Maria Pala and Anna Olivieri and Hovirag Lancioni and Kashani, {Baharak Hooshiar} and Valeria Carossa and Ekins, {Jayne E.} and Alberto G{\'o}mez-Carballa and Gabriela Huber and Bettina Zimmermann and Daniel Corach and Nora Babudri and Fausto Panara and Myres, {Natalie M.} and Walther Parson and Ornella Semino and Antonio Salas and Woodward, {Scott R.} and Alessandro Achilli and Antonio Torroni",
year = "2010",
month = "9",
day = "1",
doi = "10.1101/gr.109231.110",
language = "English",
volume = "20",
pages = "1174--1179",
journal = "Genome Research",
issn = "1088-9051",
publisher = "Cold Spring Harbor Laboratory Press",
number = "9",

}

Perego, UA, Angerhofer, N, Pala, M, Olivieri, A, Lancioni, H, Kashani, BH, Carossa, V, Ekins, JE, Gómez-Carballa, A, Huber, G, Zimmermann, B, Corach, D, Babudri, N, Panara, F, Myres, NM, Parson, W, Semino, O, Salas, A, Woodward, SR, Achilli, A & Torroni, A 2010, 'The initial peopling of the Americas: A growing number of founding mitochondrial genomes from Beringia', Genome Research, vol. 20, no. 9, pp. 1174-1179. https://doi.org/10.1101/gr.109231.110

The initial peopling of the Americas : A growing number of founding mitochondrial genomes from Beringia. / Perego, Ugo A.; Angerhofer, Norman; Pala, Maria; Olivieri, Anna; Lancioni, Hovirag; Kashani, Baharak Hooshiar; Carossa, Valeria; Ekins, Jayne E.; Gómez-Carballa, Alberto; Huber, Gabriela; Zimmermann, Bettina; Corach, Daniel; Babudri, Nora; Panara, Fausto; Myres, Natalie M.; Parson, Walther; Semino, Ornella; Salas, Antonio; Woodward, Scott R.; Achilli, Alessandro; Torroni, Antonio.

In: Genome Research, Vol. 20, No. 9, 01.09.2010, p. 1174-1179.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The initial peopling of the Americas

T2 - Genome Research

AU - Perego, Ugo A.

AU - Angerhofer, Norman

AU - Pala, Maria

AU - Olivieri, Anna

AU - Lancioni, Hovirag

AU - Kashani, Baharak Hooshiar

AU - Carossa, Valeria

AU - Ekins, Jayne E.

AU - Gómez-Carballa, Alberto

AU - Huber, Gabriela

AU - Zimmermann, Bettina

AU - Corach, Daniel

AU - Babudri, Nora

AU - Panara, Fausto

AU - Myres, Natalie M.

AU - Parson, Walther

AU - Semino, Ornella

AU - Salas, Antonio

AU - Woodward, Scott R.

AU - Achilli, Alessandro

AU - Torroni, Antonio

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages and geographical distributions that are indicative of an early arrival from Beringia with Paleo-Indians. In contrast, the estimated ages of C1d - the third subset of C1 - looked too young to fit the above scenario. To define the origin of this enigmatic C1 branch, we completely sequenced 63 C1d mitochondrial genomes from a wide range of geographically diverse, mixed, and indigenous American populations. The revised phylogeny not only brings the age of C1d within the range of that of its two sister clades, but reveals that there were two C1d founder genomes for Paleo-Indians. Thus, the recognized maternal founding lineages of Native Americans are at least 15, indicating that the overall number of Beringian or Asian founder mitochondrial genomes will probably increase extensively when all Native American haplogroups reach the same level of phylogenetic and genomic resolution as obtained here for C1d.

AB - Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages and geographical distributions that are indicative of an early arrival from Beringia with Paleo-Indians. In contrast, the estimated ages of C1d - the third subset of C1 - looked too young to fit the above scenario. To define the origin of this enigmatic C1 branch, we completely sequenced 63 C1d mitochondrial genomes from a wide range of geographically diverse, mixed, and indigenous American populations. The revised phylogeny not only brings the age of C1d within the range of that of its two sister clades, but reveals that there were two C1d founder genomes for Paleo-Indians. Thus, the recognized maternal founding lineages of Native Americans are at least 15, indicating that the overall number of Beringian or Asian founder mitochondrial genomes will probably increase extensively when all Native American haplogroups reach the same level of phylogenetic and genomic resolution as obtained here for C1d.

UR - http://www.scopus.com/inward/record.url?scp=77956276607&partnerID=8YFLogxK

U2 - 10.1101/gr.109231.110

DO - 10.1101/gr.109231.110

M3 - Article

VL - 20

SP - 1174

EP - 1179

JO - Genome Research

JF - Genome Research

SN - 1088-9051

IS - 9

ER -