The mechanisms of catalysis by β-lactamases

Anthony L. Fink, Michael Page

Research output: Chapter in Book/Report/Conference proceedingChapter


In this chapter, the catalytic mechanisms of β-lactamases are discussed in detail. After an introduction on the reactivity of compounds containing the the β-lactam ring, each class of β-lactamases is reviewed and analysed in terms of essential residues and active site chemistry. Special attention is given to class B enzymes (metallo-β-lactamases or MBLs) for which many questions remain presently unanswered and which seem to exhibit specific mechanisms depending on the subclass.
Original languageEnglish
Title of host publicationBeta-Lactamases
EditorsJean-Marie Frere
PublisherNova Science Publishers Inc
Number of pages38
ISBN (Print)9781613246382
Publication statusPublished - Dec 2012

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    Fink, A. L., & Page, M. (2012). The mechanisms of catalysis by β-lactamases. In J-M. Frere (Ed.), Beta-Lactamases (pp. 161-198). Nova Science Publishers Inc.