The mechanisms of catalysis by β-lactamases

Anthony L. Fink, Michael Page

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter, the catalytic mechanisms of β-lactamases are discussed in detail. After an introduction on the reactivity of compounds containing the the β-lactam ring, each class of β-lactamases is reviewed and analysed in terms of essential residues and active site chemistry. Special attention is given to class B enzymes (metallo-β-lactamases or MBLs) for which many questions remain presently unanswered and which seem to exhibit specific mechanisms depending on the subclass.
Original languageEnglish
Title of host publicationBeta-Lactamases
EditorsJean-Marie Frere
PublisherNova Science Publishers Inc
Chapter7
Pages161-198
Number of pages38
ISBN (Print)9781613246382
Publication statusPublished - Dec 2012

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Lactams
Catalysis
Enzymes

Cite this

Fink, A. L., & Page, M. (2012). The mechanisms of catalysis by β-lactamases. In J-M. Frere (Ed.), Beta-Lactamases (pp. 161-198). Nova Science Publishers Inc.
Fink, Anthony L. ; Page, Michael. / The mechanisms of catalysis by β-lactamases. Beta-Lactamases. editor / Jean-Marie Frere. Nova Science Publishers Inc, 2012. pp. 161-198
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Fink, AL & Page, M 2012, The mechanisms of catalysis by β-lactamases. in J-M Frere (ed.), Beta-Lactamases. Nova Science Publishers Inc, pp. 161-198.

The mechanisms of catalysis by β-lactamases. / Fink, Anthony L.; Page, Michael.

Beta-Lactamases. ed. / Jean-Marie Frere. Nova Science Publishers Inc, 2012. p. 161-198.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Fink AL, Page M. The mechanisms of catalysis by β-lactamases. In Frere J-M, editor, Beta-Lactamases. Nova Science Publishers Inc. 2012. p. 161-198