The multifaceted origin of taurine cattle reflected by the mitochondrial genome

Alessandro Achilli, Silvia Bonfiglio, Anna Olivieri, Arianna Malusà, Maria Pala, Baharak Hooshair Kashani, Ugo A. Perego, Paolo Ajmone-Marsan, Luigi Liotta, Ornella Semino, Hans Jürgen Bandelt, Luca Ferretti, Antonio Torroni

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

A Neolithic domestication of taurine cattle in the Fertile Crescent from local aurochsen (Bos primigenius) is generally accepted, but a genetic contribution from European aurochsen has been proposed. Here we performed a survey of a large number of taurine cattle mitochondrial DNA (mtDNA) control regions from numerous European breeds confirming the overall clustering within haplogroups (T1, T2 and T3) of Near Eastern ancestry, but also identifying eight mtDNAs (1.3%) that did not fit in haplogroup T. Sequencing of the entire mitochondrial genome showed that four mtDNAs formed a novel branch (haplogroup R) which, after the deep bifurcation that gave rise to the taurine and zebuine lineages, constitutes the earliest known split in the mtDNA phylogeny of B. primigenius. The remaining four mtDNAs were members of the recently discovered haplogroup Q. Phylogeographic data indicate that R mtDNAs were derived from female European aurochsen, possibly in the Italian Peninsula, and sporadically included in domestic herds. In contrast, the available data suggest that Q mtDNAs and T subclades were involved in the same Neolithic event of domestication in the Near East. Thus, the existence of novel (and rare) taurine haplogroups highlights a multifaceted genetic legacy from distinct B. primigenius populations. Taking into account that the maternally transmitted mtDNA tends to underestimate the extent of gene flow from European aurochsen, the detection of the R mtDNAs in autochthonous breeds, some of which are endangered, identifies an unexpected reservoir of genetic variation that should be carefully preserved.

Original languageEnglish
Article numbere5753
JournalPLoS One
Volume4
Issue number6
DOIs
Publication statusPublished - 1 Jun 2009
Externally publishedYes

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Mitochondrial Genome
Taurine
Genes
Mitochondrial DNA
cattle
mitochondrial DNA
taurine
domestication
Middle East
Gene Flow
breeds
Phylogeny
Cluster Analysis
gene flow
ancestry
herds
mitochondrial genome
genetic variation
Population
phylogeny

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Achilli, A., Bonfiglio, S., Olivieri, A., Malusà, A., Pala, M., Kashani, B. H., ... Torroni, A. (2009). The multifaceted origin of taurine cattle reflected by the mitochondrial genome. PLoS One, 4(6), [e5753]. https://doi.org/10.1371/journal.pone.0005753
Achilli, Alessandro ; Bonfiglio, Silvia ; Olivieri, Anna ; Malusà, Arianna ; Pala, Maria ; Kashani, Baharak Hooshair ; Perego, Ugo A. ; Ajmone-Marsan, Paolo ; Liotta, Luigi ; Semino, Ornella ; Bandelt, Hans Jürgen ; Ferretti, Luca ; Torroni, Antonio. / The multifaceted origin of taurine cattle reflected by the mitochondrial genome. In: PLoS One. 2009 ; Vol. 4, No. 6.
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Achilli, A, Bonfiglio, S, Olivieri, A, Malusà, A, Pala, M, Kashani, BH, Perego, UA, Ajmone-Marsan, P, Liotta, L, Semino, O, Bandelt, HJ, Ferretti, L & Torroni, A 2009, 'The multifaceted origin of taurine cattle reflected by the mitochondrial genome', PLoS One, vol. 4, no. 6, e5753. https://doi.org/10.1371/journal.pone.0005753

The multifaceted origin of taurine cattle reflected by the mitochondrial genome. / Achilli, Alessandro; Bonfiglio, Silvia; Olivieri, Anna; Malusà, Arianna; Pala, Maria; Kashani, Baharak Hooshair; Perego, Ugo A.; Ajmone-Marsan, Paolo; Liotta, Luigi; Semino, Ornella; Bandelt, Hans Jürgen; Ferretti, Luca; Torroni, Antonio.

In: PLoS One, Vol. 4, No. 6, e5753, 01.06.2009.

Research output: Contribution to journalArticle

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AU - Achilli, Alessandro

AU - Bonfiglio, Silvia

AU - Olivieri, Anna

AU - Malusà, Arianna

AU - Pala, Maria

AU - Kashani, Baharak Hooshair

AU - Perego, Ugo A.

AU - Ajmone-Marsan, Paolo

AU - Liotta, Luigi

AU - Semino, Ornella

AU - Bandelt, Hans Jürgen

AU - Ferretti, Luca

AU - Torroni, Antonio

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Achilli A, Bonfiglio S, Olivieri A, Malusà A, Pala M, Kashani BH et al. The multifaceted origin of taurine cattle reflected by the mitochondrial genome. PLoS One. 2009 Jun 1;4(6). e5753. https://doi.org/10.1371/journal.pone.0005753