The Naegleria genome: A free-living microbial eukaryote lends unique insights into core eukaryotic cell biology

Lillian K. Fritz-Laylin; Michael L. Ginger; Charles Walsh; Scott C. Dawson; Chandler Fulton

doi:10.1016/j.resmic.2011.03.003

The Naegleria genome: A free-living microbial eukaryote lends unique insights into core eukaryotic cell biology

Lillian K. Fritz-Laylin, Michael L. Ginger, Charles Walsh, Scott C. Dawson, Chandler Fulton

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Naegleria gruberi, a free-living protist, has long been treasured as a model for basal body and flagellar assembly due to its ability to differentiate from crawling amoebae into swimming flagellates. The full genome sequence of Naegleria gruberi has recently been used to estimate gene families ancestral to all eukaryotes and to identify novel aspects of Naegleria biology, including likely facultative anaerobic metabolism, extensive signaling cascades, and evidence for sexuality. Distinctive features of the Naegleria genome and nuclear biology provide unique perspectives for comparative cell biology, including cell division, RNA processing and nucleolar assembly. We highlight here exciting new and novel aspects of Naegleria biology identified through genomic analysis.

Original language	English
Pages (from-to)	607-618
Number of pages	12
Journal	Research in Microbiology
Volume	162
Issue number	6
Early online date	8 Mar 2011
DOIs	https://doi.org/10.1016/j.resmic.2011.03.003
Publication status	Published - 1 Jul 2011
Externally published	Yes

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title = "The Naegleria genome: A free-living microbial eukaryote lends unique insights into core eukaryotic cell biology",

abstract = "Naegleria gruberi, a free-living protist, has long been treasured as a model for basal body and flagellar assembly due to its ability to differentiate from crawling amoebae into swimming flagellates. The full genome sequence of Naegleria gruberi has recently been used to estimate gene families ancestral to all eukaryotes and to identify novel aspects of Naegleria biology, including likely facultative anaerobic metabolism, extensive signaling cascades, and evidence for sexuality. Distinctive features of the Naegleria genome and nuclear biology provide unique perspectives for comparative cell biology, including cell division, RNA processing and nucleolar assembly. We highlight here exciting new and novel aspects of Naegleria biology identified through genomic analysis.",

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AU - Walsh, Charles

AU - Dawson, Scott C.

AU - Fulton, Chandler

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AB - Naegleria gruberi, a free-living protist, has long been treasured as a model for basal body and flagellar assembly due to its ability to differentiate from crawling amoebae into swimming flagellates. The full genome sequence of Naegleria gruberi has recently been used to estimate gene families ancestral to all eukaryotes and to identify novel aspects of Naegleria biology, including likely facultative anaerobic metabolism, extensive signaling cascades, and evidence for sexuality. Distinctive features of the Naegleria genome and nuclear biology provide unique perspectives for comparative cell biology, including cell division, RNA processing and nucleolar assembly. We highlight here exciting new and novel aspects of Naegleria biology identified through genomic analysis.

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KW - Ploidy

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The Naegleria genome: A free-living microbial eukaryote lends unique insights into core eukaryotic cell biology

Abstract

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