The Naegleria genome: A free-living microbial eukaryote lends unique insights into core eukaryotic cell biology

Lillian K. Fritz-Laylin, Michael L. Ginger, Charles Walsh, Scott C. Dawson, Chandler Fulton

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Naegleria gruberi, a free-living protist, has long been treasured as a model for basal body and flagellar assembly due to its ability to differentiate from crawling amoebae into swimming flagellates. The full genome sequence of Naegleria gruberi has recently been used to estimate gene families ancestral to all eukaryotes and to identify novel aspects of Naegleria biology, including likely facultative anaerobic metabolism, extensive signaling cascades, and evidence for sexuality. Distinctive features of the Naegleria genome and nuclear biology provide unique perspectives for comparative cell biology, including cell division, RNA processing and nucleolar assembly. We highlight here exciting new and novel aspects of Naegleria biology identified through genomic analysis.

LanguageEnglish
Pages607-618
Number of pages12
JournalResearch in Microbiology
Volume162
Issue number6
Early online date8 Mar 2011
DOIs
Publication statusPublished - 1 Jul 2011
Externally publishedYes

Fingerprint

Naegleria
Eukaryotic Cells
Eukaryota
Cell Biology
Genome
Anaerobiosis
Basal Bodies
Amoeba
Aptitude
Sexuality
Cell Division
RNA
Genes

Cite this

Fritz-Laylin, Lillian K. ; Ginger, Michael L. ; Walsh, Charles ; Dawson, Scott C. ; Fulton, Chandler. / The Naegleria genome : A free-living microbial eukaryote lends unique insights into core eukaryotic cell biology. In: Research in Microbiology. 2011 ; Vol. 162, No. 6. pp. 607-618.
@article{dd555908f6954ee8a119345d6fa3382e,
title = "The Naegleria genome: A free-living microbial eukaryote lends unique insights into core eukaryotic cell biology",
abstract = "Naegleria gruberi, a free-living protist, has long been treasured as a model for basal body and flagellar assembly due to its ability to differentiate from crawling amoebae into swimming flagellates. The full genome sequence of Naegleria gruberi has recently been used to estimate gene families ancestral to all eukaryotes and to identify novel aspects of Naegleria biology, including likely facultative anaerobic metabolism, extensive signaling cascades, and evidence for sexuality. Distinctive features of the Naegleria genome and nuclear biology provide unique perspectives for comparative cell biology, including cell division, RNA processing and nucleolar assembly. We highlight here exciting new and novel aspects of Naegleria biology identified through genomic analysis.",
keywords = "Evolution, Genome, Mitosis, Naegleria, Nucleolus, Ploidy",
author = "Fritz-Laylin, {Lillian K.} and Ginger, {Michael L.} and Charles Walsh and Dawson, {Scott C.} and Chandler Fulton",
year = "2011",
month = "7",
day = "1",
doi = "10.1016/j.resmic.2011.03.003",
language = "English",
volume = "162",
pages = "607--618",
journal = "Research in Microbiology",
issn = "0923-2508",
publisher = "Elsevier Masson SAS",
number = "6",

}

The Naegleria genome : A free-living microbial eukaryote lends unique insights into core eukaryotic cell biology. / Fritz-Laylin, Lillian K.; Ginger, Michael L.; Walsh, Charles; Dawson, Scott C.; Fulton, Chandler.

In: Research in Microbiology, Vol. 162, No. 6, 01.07.2011, p. 607-618.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Naegleria genome

T2 - Research in Microbiology

AU - Fritz-Laylin, Lillian K.

AU - Ginger, Michael L.

AU - Walsh, Charles

AU - Dawson, Scott C.

AU - Fulton, Chandler

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Naegleria gruberi, a free-living protist, has long been treasured as a model for basal body and flagellar assembly due to its ability to differentiate from crawling amoebae into swimming flagellates. The full genome sequence of Naegleria gruberi has recently been used to estimate gene families ancestral to all eukaryotes and to identify novel aspects of Naegleria biology, including likely facultative anaerobic metabolism, extensive signaling cascades, and evidence for sexuality. Distinctive features of the Naegleria genome and nuclear biology provide unique perspectives for comparative cell biology, including cell division, RNA processing and nucleolar assembly. We highlight here exciting new and novel aspects of Naegleria biology identified through genomic analysis.

AB - Naegleria gruberi, a free-living protist, has long been treasured as a model for basal body and flagellar assembly due to its ability to differentiate from crawling amoebae into swimming flagellates. The full genome sequence of Naegleria gruberi has recently been used to estimate gene families ancestral to all eukaryotes and to identify novel aspects of Naegleria biology, including likely facultative anaerobic metabolism, extensive signaling cascades, and evidence for sexuality. Distinctive features of the Naegleria genome and nuclear biology provide unique perspectives for comparative cell biology, including cell division, RNA processing and nucleolar assembly. We highlight here exciting new and novel aspects of Naegleria biology identified through genomic analysis.

KW - Evolution

KW - Genome

KW - Mitosis

KW - Naegleria

KW - Nucleolus

KW - Ploidy

UR - http://www.scopus.com/inward/record.url?scp=79960009200&partnerID=8YFLogxK

U2 - 10.1016/j.resmic.2011.03.003

DO - 10.1016/j.resmic.2011.03.003

M3 - Article

VL - 162

SP - 607

EP - 618

JO - Research in Microbiology

JF - Research in Microbiology

SN - 0923-2508

IS - 6

ER -