The prediction and monitoring of toxicity associated with long-term systemic glucocorticoid therapy

Emma Harris, Ana Tiganescu, Sandy Tubeuf, Sarah Louise Mackie

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Glucocorticoids are often required for adequate control of inflammation in many serious inflammatory diseases; common indications for long-term treatment include polymyalgia rheumatica, giant cell arteritis, asthma and chronic obstructive pulmonary disease. Long-term glucocorticoid therapy is, however, associated with many adverse effects involving skin, gastro-intestinal, eye, skeletal muscle, bone, adrenal, cardio-metabolic and neuropsychiatric systems. This balance between benefits and risks of glucocorticoids is important for clinical practice and glucocorticoid-related adverse effects can significantly impair health-related quality of life. Understanding the nature and mechanisms of glucocorticoid-related adverse effects may inform how patients are monitored for toxicity and identify those groups, such as older people, that may need closer monitoring. For clinical trials in diseases commonly treated with glucocorticoids, standardised measurement of glucocorticoid-related adverse effects would facilitate future evidence synthesis and meta-analysis.

Original languageEnglish
Article number38
Number of pages10
JournalCurrent Rheumatology Reports
Volume17
Issue number6
DOIs
Publication statusPublished - 23 Apr 2015
Externally publishedYes

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