The preponderance of P450s in the Mycobacterium tuberculosis genome

Kirsty J. McLean, Daniel Clift, D. Geraint Lewis, Muna Sabri, Philip R. Balding, Michael J. Sutcliffe, David Leys, Andrew W. Munro

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

The genome of Mycobacterium tuberculosis (Mtb) encodes 20 different cytochrome P450 enzymes (P450s). P450s are mono-oxygenases, which are historically considered to facilitate prokaryotic usage of unusual carbon sources. However, their preponderance in Mtb strongly indicates crucial physiological functions, as does the fact that polycyclic azoles (known P450 inhibitors) have potent anti-mycobacterial effects. Recent structural and enzyme characterization data reveal novel features for at least two Mtb P450s (CYP121 and CYP51). Genome analysis, knockout studies and structural comparisons signify important roles in cell biology and pathogenesis for various P450s and redox partner enzymes in Mtb. Elucidation of structure, function and metabolic roles will be essential in targeting the P450s as an 'Achilles heel' in this major human pathogen.

Original languageEnglish
Pages (from-to)220-228
Number of pages9
JournalTrends in Microbiology
Volume14
Issue number5
Early online date3 Apr 2006
DOIs
Publication statusPublished - 1 May 2006
Externally publishedYes

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