The relationship between tissue levels of flavone acetic acid (NSC 37512) and site dependent anti-tumour activity in murine colon tumours

M. C. Bibby, R. M. Phillips, J. A. Double

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Abstract

Flavone acetic acid (FAA) is extremely active against subcutaneous transplantable tumours in mice, but disappointingly there has been no demonstrable clinical activity. Previous studies have shown that lung tumour deposits are less responsive than the same cells implanted subcutaneously. The aim of this study is to examine the tissue disposition of FAA in an attempt to explain this site-dependent activity. The data show clearly that FAA clearance curves are influenced by the presence of MAC 15A tumours growing either subcutaneously or systemically. The decreased clearance of FAA from MAC 15A tumour bearing animals does not however explain the resistance of lung deposits. Neither can this be explained by differences in metabolism in these different sites. Cytotoxic metabolites have not been detected either in vitro or in vivo and their role in the mechansim of action of FAA is questionable.

Original languageEnglish
Pages (from-to)541-545
Number of pages5
JournalBritish Journal of Cancer
Volume63
Issue number4
DOIs
Publication statusPublished - 1 Apr 1991
Externally publishedYes

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