The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate

Patrick Barton, Michael I. Page

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Racemic 1-phenyl-1,2-ethane diol can be resolved by the pig liver esterase catalysed hydrolysis of the corresponding cyclic carbonate to give the (R) and (S) 1-phenyl-1,2-ethane diol with an ee of 97 and 78% respectively.

Original languageEnglish
Pages (from-to)7731-7734
Number of pages4
JournalTetrahedron
Volume48
Issue number36
DOIs
Publication statusPublished - 4 Sep 1992

Fingerprint

Ethane
Carbonates
Esterases
Hydrolysis
Liver
Swine

Cite this

Barton, Patrick ; Page, Michael I. / The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate. In: Tetrahedron. 1992 ; Vol. 48, No. 36. pp. 7731-7734.
@article{676660ac2a0549da98199e89a4c9b928,
title = "The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate",
abstract = "Racemic 1-phenyl-1,2-ethane diol can be resolved by the pig liver esterase catalysed hydrolysis of the corresponding cyclic carbonate to give the (R) and (S) 1-phenyl-1,2-ethane diol with an ee of 97 and 78{\%} respectively.",
keywords = "diol resolution, pig liver esterase",
author = "Patrick Barton and Page, {Michael I.}",
year = "1992",
month = "9",
day = "4",
doi = "10.1016/S0040-4020(01)90383-7",
language = "English",
volume = "48",
pages = "7731--7734",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "36",

}

The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate. / Barton, Patrick; Page, Michael I.

In: Tetrahedron, Vol. 48, No. 36, 04.09.1992, p. 7731-7734.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate

AU - Barton, Patrick

AU - Page, Michael I.

PY - 1992/9/4

Y1 - 1992/9/4

N2 - Racemic 1-phenyl-1,2-ethane diol can be resolved by the pig liver esterase catalysed hydrolysis of the corresponding cyclic carbonate to give the (R) and (S) 1-phenyl-1,2-ethane diol with an ee of 97 and 78% respectively.

AB - Racemic 1-phenyl-1,2-ethane diol can be resolved by the pig liver esterase catalysed hydrolysis of the corresponding cyclic carbonate to give the (R) and (S) 1-phenyl-1,2-ethane diol with an ee of 97 and 78% respectively.

KW - diol resolution

KW - pig liver esterase

UR - http://www.scopus.com/inward/record.url?scp=0026746608&partnerID=8YFLogxK

U2 - 10.1016/S0040-4020(01)90383-7

DO - 10.1016/S0040-4020(01)90383-7

M3 - Article

VL - 48

SP - 7731

EP - 7734

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 36

ER -