The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate

Patrick Barton; Michael I. Page

doi:10.1016/S0040-4020(01)90383-7

The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate

Patrick Barton, Michael I. Page

School of Applied Sciences

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Racemic 1-phenyl-1,2-ethane diol can be resolved by the pig liver esterase catalysed hydrolysis of the corresponding cyclic carbonate to give the (R) and (S) 1-phenyl-1,2-ethane diol with an ee of 97 and 78% respectively.

Original language	English
Pages (from-to)	7731-7734
Number of pages	4
Journal	Tetrahedron
Volume	48
Issue number	36
DOIs	https://doi.org/10.1016/S0040-4020(01)90383-7
Publication status	Published - 4 Sep 1992

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title = "The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate",

abstract = "Racemic 1-phenyl-1,2-ethane diol can be resolved by the pig liver esterase catalysed hydrolysis of the corresponding cyclic carbonate to give the (R) and (S) 1-phenyl-1,2-ethane diol with an ee of 97 and 78% respectively.",

keywords = "diol resolution, pig liver esterase",

author = "Patrick Barton and Page, {Michael I.}",

year = "1992",

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doi = "10.1016/S0040-4020(01)90383-7",

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T1 - The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate

AU - Barton, Patrick

AU - Page, Michael I.

PY - 1992/9/4

Y1 - 1992/9/4

N2 - Racemic 1-phenyl-1,2-ethane diol can be resolved by the pig liver esterase catalysed hydrolysis of the corresponding cyclic carbonate to give the (R) and (S) 1-phenyl-1,2-ethane diol with an ee of 97 and 78% respectively.

AB - Racemic 1-phenyl-1,2-ethane diol can be resolved by the pig liver esterase catalysed hydrolysis of the corresponding cyclic carbonate to give the (R) and (S) 1-phenyl-1,2-ethane diol with an ee of 97 and 78% respectively.

KW - diol resolution

KW - pig liver esterase

UR - http://www.scopus.com/inward/record.url?scp=0026746608&partnerID=8YFLogxK

U2 - 10.1016/S0040-4020(01)90383-7

DO - 10.1016/S0040-4020(01)90383-7

M3 - Article

AN - SCOPUS:0026746608

VL - 48

SP - 7731

EP - 7734

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 36

ER -

The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate

Abstract

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