The risk of mortality and severe illness in patients infected with the omicron variant relative to delta variant of SARS-CoV-2: a systematic review and meta-analysis

Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

We summarized through systematic review and meta-analysis of observational studies the risk of mortality as well as severe illness of COVID-19 caused by omicron variant relative to delta variant of SARS-CoV-2. A total of twelve studies were included. Our results showed significantly reduced odds of mortality (pooled OR = 0.33; 95% CI: 0.16–0.67) and significantly reduced odds of severe illness (pooled OR = 0.24; 95% CI: 0.21–0.28) in patients infected with the omicron variant of SARS-CoV-2 relative to their counterparts infected with the delta variant. Findings of lower disease severity following infection with the omicron variant of SARS-CoV-2 than the delta variant are encouraging during the ongoing transition from the pandemic phase into the endemic phase of COVID-19.

Original languageEnglish
Pages (from-to)2897-2904
Number of pages8
JournalIrish Journal of Medical Science
Volume192
Issue number6
Early online date9 Feb 2023
DOIs
Publication statusPublished - 1 Dec 2023

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