Abstract
Formulations that are able to control the release of drug have become an integral part of the pharmaceutical industry. In particular oral drug delivery has been the focus of pharmaceutical research for many years. This type of drug delivery has been at the centre of research due to its many benefits over conventional dosage. The focus of this review is on matrix tablets due to their widely use and simplicity of the formulation. This includes the discussion of various types of matrix tablets and factors affecting the drug release from these formulations. The mechanism of drug release from HPMC matrices is also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 175-187 |
| Number of pages | 13 |
| Journal | BioImpacts |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2012 |
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The role of oral controlled release matrix tablets in drug delivery systems. / Nokhodchi, Ali; Raja, Shaista; Patel, Pryia; Asare-Addo, Kofi.
In: BioImpacts, Vol. 2, No. 4, 2012, p. 175-187.Research output: Contribution to journal › Article
TY - JOUR
T1 - The role of oral controlled release matrix tablets in drug delivery systems
AU - Nokhodchi, Ali
AU - Raja, Shaista
AU - Patel, Pryia
AU - Asare-Addo, Kofi
PY - 2012
Y1 - 2012
N2 - Formulations that are able to control the release of drug have become an integral part of the pharmaceutical industry. In particular oral drug delivery has been the focus of pharmaceutical research for many years. This type of drug delivery has been at the centre of research due to its many benefits over conventional dosage. The focus of this review is on matrix tablets due to their widely use and simplicity of the formulation. This includes the discussion of various types of matrix tablets and factors affecting the drug release from these formulations. The mechanism of drug release from HPMC matrices is also discussed.
AB - Formulations that are able to control the release of drug have become an integral part of the pharmaceutical industry. In particular oral drug delivery has been the focus of pharmaceutical research for many years. This type of drug delivery has been at the centre of research due to its many benefits over conventional dosage. The focus of this review is on matrix tablets due to their widely use and simplicity of the formulation. This includes the discussion of various types of matrix tablets and factors affecting the drug release from these formulations. The mechanism of drug release from HPMC matrices is also discussed.
KW - Diffusion
KW - Erosion
KW - Kinetics of drug release
KW - Matrix tablet
KW - Sustained release
UR - http://www.scopus.com/inward/record.url?scp=84876799240&partnerID=8YFLogxK
U2 - 10.5681/bi.2012.027
DO - 10.5681/bi.2012.027
M3 - Article
VL - 2
SP - 175
EP - 187
JO - BioImpacts
JF - BioImpacts
SN - 2228-5652
IS - 4
ER -