The Synthesis and Chemistry of Azolobenzodiazepines

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Approaches to the synthesis and applications of the azolobenzodiazepines have been reviewed with a particular focus on the imidazo-, pyrrolo-, pyrazolo-, and triazolo-fused systems. The review covers N-arylation, metal-catalyzed coupling processes, radiolabeled synthesis, multicomponent reactions, and the synthesis of biologically active molecules. Key natural products covered are the fuligocandins, the circumdatins, and other pyrrolobenzodiazepines. The review also covers well-known pharmaceutical substances such as flumazenil, midazolam, SJG-136, and alprazolam.

Original languageEnglish
Title of host publicationAdvances in Heterocyclic Chemistry
EditorsEric Scriven, Christopher Ramsden
PublisherElsevier
Chapter2
Pages63-103
Number of pages41
Volume123
ISBN (Print)9780128120927
DOIs
Publication statusPublished - 8 Feb 2017

Fingerprint

1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione)
Alprazolam
Flumazenil
Midazolam
Biological Products
Metals
Pharmaceutical Preparations
Drug products
Molecules
pyrrolo(2,1-c)(1,4)benzodiazepine

Cite this

Hemming, K. (2017). The Synthesis and Chemistry of Azolobenzodiazepines. In E. Scriven, & C. Ramsden (Eds.), Advances in Heterocyclic Chemistry (Vol. 123, pp. 63-103). Elsevier. Advances in Heterocyclic Chemistry https://doi.org/10.1016/bs.aihch.2016.12.001
Hemming, K. / The Synthesis and Chemistry of Azolobenzodiazepines. Advances in Heterocyclic Chemistry. editor / Eric Scriven ; Christopher Ramsden. Vol. 123 Elsevier, 2017. pp. 63-103 (Advances in Heterocyclic Chemistry).
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Hemming, K 2017, The Synthesis and Chemistry of Azolobenzodiazepines. in E Scriven & C Ramsden (eds), Advances in Heterocyclic Chemistry. vol. 123, Elsevier, Advances in Heterocyclic Chemistry, pp. 63-103. https://doi.org/10.1016/bs.aihch.2016.12.001

The Synthesis and Chemistry of Azolobenzodiazepines. / Hemming, K.

Advances in Heterocyclic Chemistry. ed. / Eric Scriven; Christopher Ramsden. Vol. 123 Elsevier, 2017. p. 63-103 (Advances in Heterocyclic Chemistry).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Hemming K. The Synthesis and Chemistry of Azolobenzodiazepines. In Scriven E, Ramsden C, editors, Advances in Heterocyclic Chemistry. Vol. 123. Elsevier. 2017. p. 63-103. (Advances in Heterocyclic Chemistry). https://doi.org/10.1016/bs.aihch.2016.12.001