The Synthesis and Chemistry of Azolobenzodiazepines

Approaches to the synthesis and applications of the azolobenzodiazepines have been reviewed with a particular focus on the imidazo-, pyrrolo-, pyrazolo-, and triazolo-fused systems. The review covers N-arylation, metal-catalyzed coupling processes, radiolabeled synthesis, multicomponent reactions, and the synthesis of biologically active molecules. Key natural products covered are the fuligocandins, the circumdatins, and other pyrrolobenzodiazepines. The review also covers well-known pharmaceutical substances such as flumazenil, midazolam, SJG-136, and alprazolam.