The TB structural genomics consortium: Providing a structural foundation for drug discovery

The TB Structural Genomics Consortium; Kirsty J. McLean

doi:10.2174/1568005023342551

The TB structural genomics consortium: Providing a structural foundation for drug discovery

The TB Structural Genomics Consortium, Kirsty J. McLean

Los Alamos National Laboratory

Research output: Contribution to journal › Review article › peer-review

79 Citations (Scopus)

Abstract

Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.

Original language	English
Pages (from-to)	121-141
Number of pages	21
Journal	Current Drug Targets - Infectious Disorders
Volume	2
Issue number	2
DOIs	https://doi.org/10.2174/1568005023342551
Publication status	Published - 2002
Externally published	Yes

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SDG 3 Good Health and Well-being

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title = "The TB structural genomics consortium: Providing a structural foundation for drug discovery",

abstract = "Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.",

keywords = "controlled study, disulfide bond, drug research, drug targeting, Mycobacterium tuberculosis, protein analysis, protein structure, structural gene, drug design",

author = "\{The TB Structural Genomics Consortium\} and Lott, \{J. Shaun\} and Terwilliger, \{Thomas C.\} and William Jacobs and Bernhard Rupp and Tom Alber and James Sacchettini and David Eisenberg and Park, \{Min S.\} and Vivek Sharma and Joel Berendzen and Munro, \{Andrew W.\} and McLean, \{Kirsty J.\} and David Leys and Arcus, \{Vickery L.\} and Baker, \{Edward N.\} and Goulding, \{Celia W.\} and Johnston, \{Jodie M.\} and Mande, \{Shekhar C.\} and Nandita Bachhawat and Avinash Kale and Radha Chauhan and \{Won Suh\}, Se and Waldo, \{Geoffrey S.\} and Jin KukYang and Kuo, \{Mack R.\} and Smith, \{Clare V.\} and Gill, \{Harindarpal S.\} and Anderson, \{Daniel H.\} and Marcin Apostol",

year = "2002",

doi = "10.2174/1568005023342551",

language = "English",

volume = "2",

pages = "121--141",

journal = "Current Drug Targets - Infectious Disorders",

issn = "1568-0053",

publisher = "Bentham Science Publishers",

number = "2",

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TY - JOUR

T1 - The TB structural genomics consortium

T2 - Providing a structural foundation for drug discovery

AU - The TB Structural Genomics Consortium

AU - Lott, J. Shaun

AU - Terwilliger, Thomas C.

AU - Jacobs, William

AU - Rupp, Bernhard

AU - Alber, Tom

AU - Sacchettini, James

AU - Eisenberg, David

AU - Park, Min S.

AU - Sharma, Vivek

AU - Berendzen, Joel

AU - Munro, Andrew W.

AU - McLean, Kirsty J.

AU - Leys, David

AU - Arcus, Vickery L.

AU - Baker, Edward N.

AU - Goulding, Celia W.

AU - Johnston, Jodie M.

AU - Mande, Shekhar C.

AU - Bachhawat, Nandita

AU - Kale, Avinash

AU - Chauhan, Radha

AU - Won Suh, Se

AU - Waldo, Geoffrey S.

AU - KukYang, Jin

AU - Kuo, Mack R.

AU - Smith, Clare V.

AU - Gill, Harindarpal S.

AU - Anderson, Daniel H.

AU - Apostol, Marcin

PY - 2002

Y1 - 2002

N2 - Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.

AB - Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.

KW - controlled study

KW - disulfide bond

KW - drug research

KW - drug targeting

KW - Mycobacterium tuberculosis

KW - protein analysis

KW - protein structure

KW - structural gene

KW - drug design

UR - https://www.scopus.com/pages/publications/0035986718

U2 - 10.2174/1568005023342551

DO - 10.2174/1568005023342551

M3 - Review article

C2 - 12462144

AN - SCOPUS:0035986718

SN - 1568-0053

VL - 2

SP - 121

EP - 141

JO - Current Drug Targets - Infectious Disorders

JF - Current Drug Targets - Infectious Disorders

IS - 2

ER -

The TB structural genomics consortium: Providing a structural foundation for drug discovery

Abstract

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