The Time Course of Changes in Retinal Vessel Diameter in Response to Differing Durations of Flicker Light Provocation

Rebekka Heitmar, Robert J. Summers

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

PURPOSE. To determine the response of retinal vessels to differing durations of flicker light (FL) stimulation. METHODS. We recorded retinal arterial and venous vessel dilation to 12.5 Hz FL provocation of varying duration (5, 7, 10, and 20 seconds) in 12 healthy young individuals (age range, 26-45 years). All participants underwent a full ocular examination including IOP and blood pressure measurements. RESULTS. Maximum dilation (MD) did not show a significant dependence on flicker duration in arteries, whereas maximum constriction (MC) did. In veins, however, MD significantly increased with flicker duration. Approximately 80% to 90% of MD in arteries is reached within 10 seconds of FL stimulation. CONCLUSIONS. The vast majority of arterial dilatory capacity is reached within 10 seconds of FL stimulation even though venous dilation continues strongly. Since MC of arteries shows a significant dependence on flicker duration, measurements at two different durations can provide more information about the retinal vascular system than at a single flicker duration alone.

Original languageEnglish
Pages (from-to)7581-7588
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume56
Issue number12
DOIs
Publication statusPublished - 1 Nov 2015
Externally publishedYes

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