The use of various organic solvents to tailor the properties of ibuprofen–glucosamine HCl solid dispersions

Ali Nokhodchi, Hiba Al-Hamidi, Adeola O. Adebisi, Kofi Asare-Addo, Mohammed Maniruzzaman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Ibuprofen is a Biopharmaceutical classification system class II drug that exhibits poor dissolution rate in the gastrointestinal tract. The aim of the present study is to enhance the dissolution of ibuprofen in presence of glucosamine. To this end, different ratios of ibuprofen:glucosamine were dissolved in various organic solvents to obtain the solid dispersions of ibuprofen–glucosamine mixtures. The solid state analysis of the samples (differential scanning calorimetry, Fourier infrared spectroscopy and X-ray powder diffraction) and the morphology (scanning electron microscope) were investigated. Particle size analysis and in vitro dissolution studies showed that the type of solvent has a significant influence on dissolution rate. Ibuprofen–glucosamine solid dispersions obtained from acetone produced better dissolution compared to that of other organic solvents. The effect of water in binary mixtures of either acetone or ethanol was also explored and the results showed that when the ratio of acetone to water was 75:25, the highest dissolution was obtained. Solid state analysis ruled out any chemical interaction between the drug and carrier even in the presence of various organic solvents which indicates a good stability of the solid dispersions to enhance the dissolution rate of ibuprofen. It was also investigated via XRPD analysis that the ibuprofen retained its crystallinity without any adverse effect on the dissolution rates. In conclusion, the present study showed that a manipulation of the organic solvent:water ratio and a change in the type of organic solvent impacted on ibuprofen–glucosamine achieving very high dissolution rate without compromising its crystallinity and physical stability.

Original languageEnglish
Pages (from-to)509-519
Number of pages11
JournalChemical Engineering Research and Design
Volume117
Early online date18 Nov 2016
DOIs
Publication statusPublished - Jan 2017

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Dispersions
Organic solvents
Dissolution
Ibuprofen
Acetone
Glucosamine
Water
Drug Carriers
Binary mixtures
Particle size analysis
X ray powder diffraction
Differential scanning calorimetry
Infrared spectroscopy
Ethanol
Electron microscopes
Scanning
Pharmaceutical Preparations

Cite this

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title = "The use of various organic solvents to tailor the properties of ibuprofen–glucosamine HCl solid dispersions",
abstract = "Ibuprofen is a Biopharmaceutical classification system class II drug that exhibits poor dissolution rate in the gastrointestinal tract. The aim of the present study is to enhance the dissolution of ibuprofen in presence of glucosamine. To this end, different ratios of ibuprofen:glucosamine were dissolved in various organic solvents to obtain the solid dispersions of ibuprofen–glucosamine mixtures. The solid state analysis of the samples (differential scanning calorimetry, Fourier infrared spectroscopy and X-ray powder diffraction) and the morphology (scanning electron microscope) were investigated. Particle size analysis and in vitro dissolution studies showed that the type of solvent has a significant influence on dissolution rate. Ibuprofen–glucosamine solid dispersions obtained from acetone produced better dissolution compared to that of other organic solvents. The effect of water in binary mixtures of either acetone or ethanol was also explored and the results showed that when the ratio of acetone to water was 75:25, the highest dissolution was obtained. Solid state analysis ruled out any chemical interaction between the drug and carrier even in the presence of various organic solvents which indicates a good stability of the solid dispersions to enhance the dissolution rate of ibuprofen. It was also investigated via XRPD analysis that the ibuprofen retained its crystallinity without any adverse effect on the dissolution rates. In conclusion, the present study showed that a manipulation of the organic solvent:water ratio and a change in the type of organic solvent impacted on ibuprofen–glucosamine achieving very high dissolution rate without compromising its crystallinity and physical stability.",
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author = "Ali Nokhodchi and Hiba Al-Hamidi and Adebisi, {Adeola O.} and Kofi Asare-Addo and Mohammed Maniruzzaman",
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The use of various organic solvents to tailor the properties of ibuprofen–glucosamine HCl solid dispersions. / Nokhodchi, Ali; Al-Hamidi, Hiba; Adebisi, Adeola O.; Asare-Addo, Kofi; Maniruzzaman, Mohammed.

In: Chemical Engineering Research and Design, Vol. 117, 01.2017, p. 509-519.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The use of various organic solvents to tailor the properties of ibuprofen–glucosamine HCl solid dispersions

AU - Nokhodchi, Ali

AU - Al-Hamidi, Hiba

AU - Adebisi, Adeola O.

AU - Asare-Addo, Kofi

AU - Maniruzzaman, Mohammed

N1 - Not OA compliant. AAM deposited in ePrints 10 months after online publication date.

PY - 2017/1

Y1 - 2017/1

N2 - Ibuprofen is a Biopharmaceutical classification system class II drug that exhibits poor dissolution rate in the gastrointestinal tract. The aim of the present study is to enhance the dissolution of ibuprofen in presence of glucosamine. To this end, different ratios of ibuprofen:glucosamine were dissolved in various organic solvents to obtain the solid dispersions of ibuprofen–glucosamine mixtures. The solid state analysis of the samples (differential scanning calorimetry, Fourier infrared spectroscopy and X-ray powder diffraction) and the morphology (scanning electron microscope) were investigated. Particle size analysis and in vitro dissolution studies showed that the type of solvent has a significant influence on dissolution rate. Ibuprofen–glucosamine solid dispersions obtained from acetone produced better dissolution compared to that of other organic solvents. The effect of water in binary mixtures of either acetone or ethanol was also explored and the results showed that when the ratio of acetone to water was 75:25, the highest dissolution was obtained. Solid state analysis ruled out any chemical interaction between the drug and carrier even in the presence of various organic solvents which indicates a good stability of the solid dispersions to enhance the dissolution rate of ibuprofen. It was also investigated via XRPD analysis that the ibuprofen retained its crystallinity without any adverse effect on the dissolution rates. In conclusion, the present study showed that a manipulation of the organic solvent:water ratio and a change in the type of organic solvent impacted on ibuprofen–glucosamine achieving very high dissolution rate without compromising its crystallinity and physical stability.

AB - Ibuprofen is a Biopharmaceutical classification system class II drug that exhibits poor dissolution rate in the gastrointestinal tract. The aim of the present study is to enhance the dissolution of ibuprofen in presence of glucosamine. To this end, different ratios of ibuprofen:glucosamine were dissolved in various organic solvents to obtain the solid dispersions of ibuprofen–glucosamine mixtures. The solid state analysis of the samples (differential scanning calorimetry, Fourier infrared spectroscopy and X-ray powder diffraction) and the morphology (scanning electron microscope) were investigated. Particle size analysis and in vitro dissolution studies showed that the type of solvent has a significant influence on dissolution rate. Ibuprofen–glucosamine solid dispersions obtained from acetone produced better dissolution compared to that of other organic solvents. The effect of water in binary mixtures of either acetone or ethanol was also explored and the results showed that when the ratio of acetone to water was 75:25, the highest dissolution was obtained. Solid state analysis ruled out any chemical interaction between the drug and carrier even in the presence of various organic solvents which indicates a good stability of the solid dispersions to enhance the dissolution rate of ibuprofen. It was also investigated via XRPD analysis that the ibuprofen retained its crystallinity without any adverse effect on the dissolution rates. In conclusion, the present study showed that a manipulation of the organic solvent:water ratio and a change in the type of organic solvent impacted on ibuprofen–glucosamine achieving very high dissolution rate without compromising its crystallinity and physical stability.

KW - Dissolution rate

KW - Glucosamine HCl

KW - Ibuprofen

KW - Organic solvents

KW - Solid dispersion

KW - Solid state analysis

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DO - 10.1016/j.cherd.2016.11.004

M3 - Article

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SP - 509

EP - 519

JO - Chemical Engineering Research and Design

JF - Chemical Engineering Research and Design

SN - 0263-8762

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