The use of visible and UV dissolution imaging for the assessment of propranolol hydrochloride in liquisolid compacts of Sesamum radiatum gum

Adam Ward, Karl Walton, Slavena Stoycheva, Matthew Wallis, Adeola Adebisi, Elijah Nep, Ndidi Ngwuluka, Seham Shaboun, Alan Smith, Barbara Conway, Kofi Asare-Addo

Research output: Contribution to journalArticle

Abstract

This work explores the first use of UV imaging in liquisolid systems. The aim of this study was to simultaneously measure a model drug propranolol hydrochloride (PPN) release and compact swelling behaviour from liquisolid systems using sesamum radiatum gum by exploiting the visible and UV imaging capabilities of the novel surface dissolution instrument (SDI2). Liquisolid compacts were successfully prepared using polysorbate 80 as the liquid solvent. The influence of either colloidal silica or veegum (magnesium aluminium silicate) was also evaluated in the liquisolid sesamum gum compacts. Solid-state characterization using differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) showed a decrease in the crystallinity of the model cationic drug. Visible and UV imaging was successfully used to detect differences between the conventional or physical mixture formulations containing veegum or colloidal silica and the liquisolid preparations as well as differences between their swelling behaviour. The use of this imaging technique provides added insights into the drug release behaviour of formulations.
Original languageEnglish
Article number101511
Number of pages8
JournalJournal of Drug Delivery Science and Technology
Volume56
Issue numberA
Early online date9 Jan 2020
DOIs
Publication statusPublished - 1 Apr 2020

    Fingerprint

Cite this