The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

Chia Siang Kow, Syed Shahzad Hasan, Dinesh Sangarran Ramachandram

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Background and Aims
Vitamin C appears to be a viable treatment option for patients with COVID-19.

Methods
We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) of vitamin C versus comparative interventions in patients with COVID-19. The outcome of interest was all-cause mortality.

Results
The meta-analysis of eleven trials using a random-effects model revealed significant reduction in the risk of all-cause mortality with the administration of vitamin C among patients with COVID-19 relative to no vitamin C (pooled odds ratio = 0.53; 95% confidence interval 0.30–0.92). Subgroup analysis of studies that included patients with severe COVID-19 also produced findings of significant mortality reduction with the administration of vitamin C relative to no vitamin C (pooled odds ratio = 0.47; 95% confidence interval 0.26–0.84).

Conclusion
Overall, evidence from RCTs suggests a survival benefit for vitamin C in patients with severe COVID-19. However, we should await data from large-scale randomized trials to affirm its mortality benefits.
Original languageEnglish
Pages (from-to)3357-3362
Number of pages6
JournalInflammopharmacology
Volume31
Issue number6
Early online date18 Apr 2023
DOIs
Publication statusPublished - 1 Dec 2023

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