The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

Chia Siang Kow; Syed Shahzad Hasan; Dinesh Sangarran Ramachandram

doi:10.1007/s10787-023-01200-5

The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

Chia Siang Kow, Syed Shahzad Hasan, Dinesh Sangarran Ramachandram

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

Background and Aims
Vitamin C appears to be a viable treatment option for patients with COVID-19.

Methods
We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) of vitamin C versus comparative interventions in patients with COVID-19. The outcome of interest was all-cause mortality.

Results
The meta-analysis of eleven trials using a random-effects model revealed significant reduction in the risk of all-cause mortality with the administration of vitamin C among patients with COVID-19 relative to no vitamin C (pooled odds ratio = 0.53; 95% confidence interval 0.30–0.92). Subgroup analysis of studies that included patients with severe COVID-19 also produced findings of significant mortality reduction with the administration of vitamin C relative to no vitamin C (pooled odds ratio = 0.47; 95% confidence interval 0.26–0.84).

Conclusion
Overall, evidence from RCTs suggests a survival benefit for vitamin C in patients with severe COVID-19. However, we should await data from large-scale randomized trials to affirm its mortality benefits.

Original language	English
Pages (from-to)	3357-3362
Number of pages	6
Journal	Inflammopharmacology
Volume	31
Issue number	6
Early online date	18 Apr 2023
DOIs	https://doi.org/10.1007/s10787-023-01200-5
Publication status	Published - 1 Dec 2023

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SDG 3 Good Health and Well-being

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Cite this

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title = "The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials",

abstract = "Background and Aims Vitamin C appears to be a viable treatment option for patients with COVID-19. Methods We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) of vitamin C versus comparative interventions in patients with COVID-19. The outcome of interest was all-cause mortality. Results The meta-analysis of eleven trials using a random-effects model revealed significant reduction in the risk of all-cause mortality with the administration of vitamin C among patients with COVID-19 relative to no vitamin C (pooled odds ratio = 0.53; 95\% confidence interval 0.30–0.92). Subgroup analysis of studies that included patients with severe COVID-19 also produced findings of significant mortality reduction with the administration of vitamin C relative to no vitamin C (pooled odds ratio = 0.47; 95\% confidence interval 0.26–0.84). Conclusion Overall, evidence from RCTs suggests a survival benefit for vitamin C in patients with severe COVID-19. However, we should await data from large-scale randomized trials to affirm its mortality benefits.",

keywords = "Ascorbic acid, COVID 19, Mortality, Vitamin C, COVID-19, Ascorbic acid",

author = "Kow, \{Chia Siang\} and Hasan, \{Syed Shahzad\} and Ramachandram, \{Dinesh Sangarran\}",

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doi = "10.1007/s10787-023-01200-5",

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T1 - The effect of vitamin C on the risk of mortality in patients with COVID-19

T2 - a systematic review and meta-analysis of randomized controlled trials

AU - Kow, Chia Siang

AU - Hasan, Syed Shahzad

AU - Ramachandram, Dinesh Sangarran

PY - 2023/12/1

Y1 - 2023/12/1

N2 - Background and Aims Vitamin C appears to be a viable treatment option for patients with COVID-19. Methods We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) of vitamin C versus comparative interventions in patients with COVID-19. The outcome of interest was all-cause mortality. Results The meta-analysis of eleven trials using a random-effects model revealed significant reduction in the risk of all-cause mortality with the administration of vitamin C among patients with COVID-19 relative to no vitamin C (pooled odds ratio = 0.53; 95% confidence interval 0.30–0.92). Subgroup analysis of studies that included patients with severe COVID-19 also produced findings of significant mortality reduction with the administration of vitamin C relative to no vitamin C (pooled odds ratio = 0.47; 95% confidence interval 0.26–0.84). Conclusion Overall, evidence from RCTs suggests a survival benefit for vitamin C in patients with severe COVID-19. However, we should await data from large-scale randomized trials to affirm its mortality benefits.

AB - Background and Aims Vitamin C appears to be a viable treatment option for patients with COVID-19. Methods We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) of vitamin C versus comparative interventions in patients with COVID-19. The outcome of interest was all-cause mortality. Results The meta-analysis of eleven trials using a random-effects model revealed significant reduction in the risk of all-cause mortality with the administration of vitamin C among patients with COVID-19 relative to no vitamin C (pooled odds ratio = 0.53; 95% confidence interval 0.30–0.92). Subgroup analysis of studies that included patients with severe COVID-19 also produced findings of significant mortality reduction with the administration of vitamin C relative to no vitamin C (pooled odds ratio = 0.47; 95% confidence interval 0.26–0.84). Conclusion Overall, evidence from RCTs suggests a survival benefit for vitamin C in patients with severe COVID-19. However, we should await data from large-scale randomized trials to affirm its mortality benefits.

KW - Ascorbic acid

KW - COVID 19

KW - Mortality

KW - Vitamin C

KW - COVID-19

KW - Ascorbic acid

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DO - 10.1007/s10787-023-01200-5

M3 - Review article

C2 - 37071316

SN - 0925-4692

VL - 31

SP - 3357

EP - 3362

JO - Inflammopharmacology

JF - Inflammopharmacology

IS - 6

ER -

The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

Abstract

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