Thermodynamics of micellisation: Sodium dodecyl sulfate/sodium deoxycholate with polyethylene glycol and model drugs

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Abstract

Variations in the critical micelle concentration (CMC) have been determined for sodium dodecyl sulfate and sodium deoxycholate (NaDC) in the presence of five drugs and polyethylene glycol (PEG) at temperatures (298.2, 304.2 and 310.2) K. From these data, thermodynamic parameters associated with the micellisation process (DmicG, DmicH and DmicS) were calculated. In the presence of some drug-based compounds, the CMC of SDS was affected, for example the presence of PEG dramatically reduced the CMC in all cases. Furthermore, PEG appeared to reduce the enthalpy of micellisation for all scenarios with only comparatively minor variations in the change in Gibbs free energy for the processes observed. For NaDC, the calorimetric results were far less predictable. A primary aggregation event recorded at a comparatively low concentration failed to appear for NaDC in the presence of a secondary compound, such as a drug or PEG. For NaDC, the presence of PEG had little effect on the CMC and corresponding thermodynamic data.
LanguageEnglish
Pages77-81
Number of pages5
JournalJournal of Chemical Thermodynamics
Volume77
DOIs
Publication statusPublished - 1 Oct 2014

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Micellization
Deoxycholic Acid
Sodium dodecyl sulfate
sodium sulfates
Sodium Dodecyl Sulfate
Critical micelle concentration
Polyethylene glycols
glycols
polyethylenes
drugs
Sodium
sodium
Thermodynamics
micelles
thermodynamics
Pharmaceutical Preparations
Gibbs free energy
low concentrations
Enthalpy
Agglomeration

Cite this

@article{af828182eb5a45bcb53da67af18e45d3,
title = "Thermodynamics of micellisation: Sodium dodecyl sulfate/sodium deoxycholate with polyethylene glycol and model drugs",
abstract = "Variations in the critical micelle concentration (CMC) have been determined for sodium dodecyl sulfate and sodium deoxycholate (NaDC) in the presence of five drugs and polyethylene glycol (PEG) at temperatures (298.2, 304.2 and 310.2) K. From these data, thermodynamic parameters associated with the micellisation process (DmicG, DmicH and DmicS) were calculated. In the presence of some drug-based compounds, the CMC of SDS was affected, for example the presence of PEG dramatically reduced the CMC in all cases. Furthermore, PEG appeared to reduce the enthalpy of micellisation for all scenarios with only comparatively minor variations in the change in Gibbs free energy for the processes observed. For NaDC, the calorimetric results were far less predictable. A primary aggregation event recorded at a comparatively low concentration failed to appear for NaDC in the presence of a secondary compound, such as a drug or PEG. For NaDC, the presence of PEG had little effect on the CMC and corresponding thermodynamic data.",
author = "Waters, {Laura J.} and Talib Hussain and Parkes, {Gareth M.B}",
year = "2014",
month = "10",
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doi = "10.1016/j.jct.2014.05.004",
language = "English",
volume = "77",
pages = "77--81",
journal = "Journal of Chemical Thermodynamics",
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TY - JOUR

T1 - Thermodynamics of micellisation: Sodium dodecyl sulfate/sodium deoxycholate with polyethylene glycol and model drugs

AU - Waters, Laura J.

AU - Hussain, Talib

AU - Parkes, Gareth M.B

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Variations in the critical micelle concentration (CMC) have been determined for sodium dodecyl sulfate and sodium deoxycholate (NaDC) in the presence of five drugs and polyethylene glycol (PEG) at temperatures (298.2, 304.2 and 310.2) K. From these data, thermodynamic parameters associated with the micellisation process (DmicG, DmicH and DmicS) were calculated. In the presence of some drug-based compounds, the CMC of SDS was affected, for example the presence of PEG dramatically reduced the CMC in all cases. Furthermore, PEG appeared to reduce the enthalpy of micellisation for all scenarios with only comparatively minor variations in the change in Gibbs free energy for the processes observed. For NaDC, the calorimetric results were far less predictable. A primary aggregation event recorded at a comparatively low concentration failed to appear for NaDC in the presence of a secondary compound, such as a drug or PEG. For NaDC, the presence of PEG had little effect on the CMC and corresponding thermodynamic data.

AB - Variations in the critical micelle concentration (CMC) have been determined for sodium dodecyl sulfate and sodium deoxycholate (NaDC) in the presence of five drugs and polyethylene glycol (PEG) at temperatures (298.2, 304.2 and 310.2) K. From these data, thermodynamic parameters associated with the micellisation process (DmicG, DmicH and DmicS) were calculated. In the presence of some drug-based compounds, the CMC of SDS was affected, for example the presence of PEG dramatically reduced the CMC in all cases. Furthermore, PEG appeared to reduce the enthalpy of micellisation for all scenarios with only comparatively minor variations in the change in Gibbs free energy for the processes observed. For NaDC, the calorimetric results were far less predictable. A primary aggregation event recorded at a comparatively low concentration failed to appear for NaDC in the presence of a secondary compound, such as a drug or PEG. For NaDC, the presence of PEG had little effect on the CMC and corresponding thermodynamic data.

U2 - 10.1016/j.jct.2014.05.004

DO - 10.1016/j.jct.2014.05.004

M3 - Article

VL - 77

SP - 77

EP - 81

JO - Journal of Chemical Thermodynamics

T2 - Journal of Chemical Thermodynamics

JF - Journal of Chemical Thermodynamics

SN - 0021-9614

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