Time-dependent neuronal changes associated with craving in opioid dependence: an FMRI study

Anna Murphy, Dan I. Lubman, Sarah McKie, Prun S. Bijral, Lesley A. Peters, Sophie E. Holmes, Ian M. Anderson, Bill Deakin, Rebecca Elliott

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Relapse after initially successful treatment is a significant problem facing the treatment of opioid dependence. Evidence suggests craving elicited by re-exposure to drug cues may precipitate relapse. Attempts to identify neural biomarkers of cue-elicited craving have yielded inconsistent findings. We aimed to apply a novel continuous functional magnetic resonance imaging technique to follow the minute-to-minute evolution of brain responses, which correlate with the waxing and waning of craving. Newly detoxified male opioid-dependent patients and healthy control participants attended two separate, counterbalanced, functional magnetic resonance imaging scanning sessions during which they viewed a 10-minute video (drug cue or neutral cue) followed by 5 minutes of fixation. Participants rated the intensity of their craving throughout each session. We hypothesized that subcortical/ventral prefrontal cortex (PFC) regions and dorsal PFC regions would show different associations with craving reflecting their putative roles in appetitive processing versus cognitive control. Compared with controls, drug cue (minus neutral cue) video recruited the left amygdala and was temporally correlated with craving. In contrast, dorsal anterior cingulate blood-oxygen-level-dependent signal time course was higher than controls only during a period after cue exposure when craving levels were declining. Against expectations, neither the ventral striatum nor ventral PFC was significantly recruited by drug cue exposure. Findings suggest that the amygdala has a central role in craving, whereas the dorsal anterior cingulate may control craving in treatment-seeking patients. Time course analysis yielded new insights into the neural substrates of craving that could objectively validate development of psychological and pharmacological approaches to sustained abstinence.
LanguageEnglish
Pages1168-1178
Number of pages11
JournalAddiction Biology
Volume23
Issue number5
Early online date22 Sep 2017
DOIs
Publication statusPublished - Sep 2018

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Opioid Analgesics
Cues
Prefrontal Cortex
Gyrus Cinguli
Amygdala
Magnetic Resonance Imaging
Craving
Pharmaceutical Preparations
Recurrence
Drug and Narcotic Control
Healthy Volunteers
Therapeutics
Biomarkers
Pharmacology
Psychology
Oxygen
Brain

Cite this

Murphy, A., Lubman, D. I., McKie, S., Bijral, P. S., Peters, L. A., Holmes, S. E., ... Elliott, R. (2018). Time-dependent neuronal changes associated with craving in opioid dependence: an FMRI study. Addiction Biology, 23(5), 1168-1178. https://doi.org/10.1111/adb.12554
Murphy, Anna ; Lubman, Dan I. ; McKie, Sarah ; Bijral, Prun S. ; Peters, Lesley A. ; Holmes, Sophie E. ; Anderson, Ian M. ; Deakin, Bill ; Elliott, Rebecca. / Time-dependent neuronal changes associated with craving in opioid dependence : an FMRI study. In: Addiction Biology. 2018 ; Vol. 23, No. 5. pp. 1168-1178.
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abstract = "Relapse after initially successful treatment is a significant problem facing the treatment of opioid dependence. Evidence suggests craving elicited by re-exposure to drug cues may precipitate relapse. Attempts to identify neural biomarkers of cue-elicited craving have yielded inconsistent findings. We aimed to apply a novel continuous functional magnetic resonance imaging technique to follow the minute-to-minute evolution of brain responses, which correlate with the waxing and waning of craving. Newly detoxified male opioid-dependent patients and healthy control participants attended two separate, counterbalanced, functional magnetic resonance imaging scanning sessions during which they viewed a 10-minute video (drug cue or neutral cue) followed by 5 minutes of fixation. Participants rated the intensity of their craving throughout each session. We hypothesized that subcortical/ventral prefrontal cortex (PFC) regions and dorsal PFC regions would show different associations with craving reflecting their putative roles in appetitive processing versus cognitive control. Compared with controls, drug cue (minus neutral cue) video recruited the left amygdala and was temporally correlated with craving. In contrast, dorsal anterior cingulate blood-oxygen-level-dependent signal time course was higher than controls only during a period after cue exposure when craving levels were declining. Against expectations, neither the ventral striatum nor ventral PFC was significantly recruited by drug cue exposure. Findings suggest that the amygdala has a central role in craving, whereas the dorsal anterior cingulate may control craving in treatment-seeking patients. Time course analysis yielded new insights into the neural substrates of craving that could objectively validate development of psychological and pharmacological approaches to sustained abstinence.",
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Murphy, A, Lubman, DI, McKie, S, Bijral, PS, Peters, LA, Holmes, SE, Anderson, IM, Deakin, B & Elliott, R 2018, 'Time-dependent neuronal changes associated with craving in opioid dependence: an FMRI study', Addiction Biology, vol. 23, no. 5, pp. 1168-1178. https://doi.org/10.1111/adb.12554

Time-dependent neuronal changes associated with craving in opioid dependence : an FMRI study. / Murphy, Anna; Lubman, Dan I.; McKie, Sarah; Bijral, Prun S.; Peters, Lesley A.; Holmes, Sophie E.; Anderson, Ian M.; Deakin, Bill; Elliott, Rebecca.

In: Addiction Biology, Vol. 23, No. 5, 09.2018, p. 1168-1178.

Research output: Contribution to journalArticle

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AU - Murphy, Anna

AU - Lubman, Dan I.

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AU - Bijral, Prun S.

AU - Peters, Lesley A.

AU - Holmes, Sophie E.

AU - Anderson, Ian M.

AU - Deakin, Bill

AU - Elliott, Rebecca

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N2 - Relapse after initially successful treatment is a significant problem facing the treatment of opioid dependence. Evidence suggests craving elicited by re-exposure to drug cues may precipitate relapse. Attempts to identify neural biomarkers of cue-elicited craving have yielded inconsistent findings. We aimed to apply a novel continuous functional magnetic resonance imaging technique to follow the minute-to-minute evolution of brain responses, which correlate with the waxing and waning of craving. Newly detoxified male opioid-dependent patients and healthy control participants attended two separate, counterbalanced, functional magnetic resonance imaging scanning sessions during which they viewed a 10-minute video (drug cue or neutral cue) followed by 5 minutes of fixation. Participants rated the intensity of their craving throughout each session. We hypothesized that subcortical/ventral prefrontal cortex (PFC) regions and dorsal PFC regions would show different associations with craving reflecting their putative roles in appetitive processing versus cognitive control. Compared with controls, drug cue (minus neutral cue) video recruited the left amygdala and was temporally correlated with craving. In contrast, dorsal anterior cingulate blood-oxygen-level-dependent signal time course was higher than controls only during a period after cue exposure when craving levels were declining. Against expectations, neither the ventral striatum nor ventral PFC was significantly recruited by drug cue exposure. Findings suggest that the amygdala has a central role in craving, whereas the dorsal anterior cingulate may control craving in treatment-seeking patients. Time course analysis yielded new insights into the neural substrates of craving that could objectively validate development of psychological and pharmacological approaches to sustained abstinence.

AB - Relapse after initially successful treatment is a significant problem facing the treatment of opioid dependence. Evidence suggests craving elicited by re-exposure to drug cues may precipitate relapse. Attempts to identify neural biomarkers of cue-elicited craving have yielded inconsistent findings. We aimed to apply a novel continuous functional magnetic resonance imaging technique to follow the minute-to-minute evolution of brain responses, which correlate with the waxing and waning of craving. Newly detoxified male opioid-dependent patients and healthy control participants attended two separate, counterbalanced, functional magnetic resonance imaging scanning sessions during which they viewed a 10-minute video (drug cue or neutral cue) followed by 5 minutes of fixation. Participants rated the intensity of their craving throughout each session. We hypothesized that subcortical/ventral prefrontal cortex (PFC) regions and dorsal PFC regions would show different associations with craving reflecting their putative roles in appetitive processing versus cognitive control. Compared with controls, drug cue (minus neutral cue) video recruited the left amygdala and was temporally correlated with craving. In contrast, dorsal anterior cingulate blood-oxygen-level-dependent signal time course was higher than controls only during a period after cue exposure when craving levels were declining. Against expectations, neither the ventral striatum nor ventral PFC was significantly recruited by drug cue exposure. Findings suggest that the amygdala has a central role in craving, whereas the dorsal anterior cingulate may control craving in treatment-seeking patients. Time course analysis yielded new insights into the neural substrates of craving that could objectively validate development of psychological and pharmacological approaches to sustained abstinence.

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KW - fMRI

KW - Cues

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