Titration calorimetry of surfactant-drug interactions

Micelle formation and saturation studies

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20 Citations (Scopus)

Abstract

Isothermal titration calorimetry (ITC) was employed to monitor the addition of five model drugs to anionic surfactant based micelles, composed of sodium dodecyl sulfate (SDS), through to the point at which they were saturated with drug. Analysis of the resultant data using this newly developed method has confirmed the suitability of the technique to acquire such data with saturation limits established in all cases. Values for the point at which saturation occurred ranged from 17 molecules of theophylline per micelle at T = 298 K up to 63 molecules of caffeine per micelle at 310 K. Micellar systems can be disrupted by the presence of additional chemicals, such as the drugs used in this study, therefore a separate investigation was undertaken to determine the critical micellar concentration (CMC) for SDS in the presence of each drug at T = 298 K and 310 K using ITC. In the majority of cases, there was no appreciable alteration to the CMC of SDS with drug present.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalJournal of Chemical Thermodynamics
Volume53
DOIs
Publication statusPublished - Oct 2012

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Drug interactions
Sodium dodecyl sulfate
Micelles
Calorimetry
Titration
Surface-Active Agents
titration
micelles
drugs
Surface active agents
heat measurement
surfactants
saturation
sodium sulfates
Sodium Dodecyl Sulfate
Pharmaceutical Preparations
Caffeine
Molecules
Anionic surfactants
interactions

Cite this

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title = "Titration calorimetry of surfactant-drug interactions: Micelle formation and saturation studies",
abstract = "Isothermal titration calorimetry (ITC) was employed to monitor the addition of five model drugs to anionic surfactant based micelles, composed of sodium dodecyl sulfate (SDS), through to the point at which they were saturated with drug. Analysis of the resultant data using this newly developed method has confirmed the suitability of the technique to acquire such data with saturation limits established in all cases. Values for the point at which saturation occurred ranged from 17 molecules of theophylline per micelle at T = 298 K up to 63 molecules of caffeine per micelle at 310 K. Micellar systems can be disrupted by the presence of additional chemicals, such as the drugs used in this study, therefore a separate investigation was undertaken to determine the critical micellar concentration (CMC) for SDS in the presence of each drug at T = 298 K and 310 K using ITC. In the majority of cases, there was no appreciable alteration to the CMC of SDS with drug present.",
keywords = "Calorimetry, CMC, Drugs, ITC, Micelles, Saturation",
author = "Waters, {Laura J.} and Talib Hussain and Parkes, {Gareth M.B.}",
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journal = "Journal of Chemical Thermodynamics",
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TY - JOUR

T1 - Titration calorimetry of surfactant-drug interactions

T2 - Micelle formation and saturation studies

AU - Waters, Laura J.

AU - Hussain, Talib

AU - Parkes, Gareth M.B.

PY - 2012/10

Y1 - 2012/10

N2 - Isothermal titration calorimetry (ITC) was employed to monitor the addition of five model drugs to anionic surfactant based micelles, composed of sodium dodecyl sulfate (SDS), through to the point at which they were saturated with drug. Analysis of the resultant data using this newly developed method has confirmed the suitability of the technique to acquire such data with saturation limits established in all cases. Values for the point at which saturation occurred ranged from 17 molecules of theophylline per micelle at T = 298 K up to 63 molecules of caffeine per micelle at 310 K. Micellar systems can be disrupted by the presence of additional chemicals, such as the drugs used in this study, therefore a separate investigation was undertaken to determine the critical micellar concentration (CMC) for SDS in the presence of each drug at T = 298 K and 310 K using ITC. In the majority of cases, there was no appreciable alteration to the CMC of SDS with drug present.

AB - Isothermal titration calorimetry (ITC) was employed to monitor the addition of five model drugs to anionic surfactant based micelles, composed of sodium dodecyl sulfate (SDS), through to the point at which they were saturated with drug. Analysis of the resultant data using this newly developed method has confirmed the suitability of the technique to acquire such data with saturation limits established in all cases. Values for the point at which saturation occurred ranged from 17 molecules of theophylline per micelle at T = 298 K up to 63 molecules of caffeine per micelle at 310 K. Micellar systems can be disrupted by the presence of additional chemicals, such as the drugs used in this study, therefore a separate investigation was undertaken to determine the critical micellar concentration (CMC) for SDS in the presence of each drug at T = 298 K and 310 K using ITC. In the majority of cases, there was no appreciable alteration to the CMC of SDS with drug present.

KW - Calorimetry

KW - CMC

KW - Drugs

KW - ITC

KW - Micelles

KW - Saturation

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DO - 10.1016/j.jct.2012.04.021

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