Triazole-based, optically-pure metallosupramolecules: highly potent and selective anticancer compounds

Hualong Song, Nicola Rogers, Viktor Brabec, Guy Clarkson, James P.C. Coverdale, Hana Kostrhunova, Roger Phillips, Miles Postings, Samantha Shepherd, Peter Scott

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Abstract

Functionalised triazole aldehydes are used in the highly selective self-assembly of water compatible, optically pure, low symmetry Fe(II)- and Zn(II)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.
Original languageEnglish
Pages (from-to)6392-6395
Number of pages4
JournalChemical Communications
Volume56
Issue number47
Early online date29 Apr 2020
DOIs
Publication statusPublished - 14 Jun 2020

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    Song, H., Rogers, N., Brabec, V., Clarkson, G., Coverdale, J. P. C., Kostrhunova, H., Phillips, R., Postings, M., Shepherd, S., & Scott, P. (2020). Triazole-based, optically-pure metallosupramolecules: highly potent and selective anticancer compounds. Chemical Communications, 56(47), 6392-6395. https://doi.org/10.1039/D0CC02429E