Functionalised triazole aldehydes are used in the highly selective self-assembly of water compatible, optically pure, low symmetry Fe(II)- and Zn(II)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.
Song, H., Rogers, N., Brabec, V., Clarkson, G., Coverdale, J. P. C., Kostrhunova, H., Phillips, R., Postings, M., Shepherd, S., & Scott, P. (2020). Triazole-based, optically-pure metallosupramolecules: highly potent and selective anticancer compounds. Chemical Communications, 56(47), 6392-6395. https://doi.org/10.1039/D0CC02429E