Triazole-based, optically-pure metallosupramolecules: highly potent and selective anticancer compounds

Hualong Song; Nicola Rogers; Viktor Brabec; Guy Clarkson; James P.C. Coverdale; Hana Kostrhunova; Roger Phillips; Miles Postings; Samantha Shepherd; Peter Scott

doi:10.1039/D0CC02429E

Triazole-based, optically-pure metallosupramolecules: highly potent and selective anticancer compounds

Hualong Song, Nicola Rogers, Viktor Brabec, Guy Clarkson, James P.C. Coverdale, Hana Kostrhunova, Roger Phillips, Miles Postings, Samantha Shepherd, Peter Scott

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Functionalised triazole aldehydes are used in the highly selective self-assembly of water compatible, optically pure, low symmetry Fe(II)- and Zn(II)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.

Original language	English
Pages (from-to)	6392-6395
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	47
Early online date	29 Apr 2020
DOIs	https://doi.org/10.1039/D0CC02429E
Publication status	Published - 14 Jun 2020

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abstract = "Functionalised triazole aldehydes are used in the highly selective self-assembly of water compatible, optically pure, low symmetry Fe(II)- and Zn(II)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.",

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AU - Rogers, Nicola

AU - Brabec, Viktor

AU - Clarkson, Guy

AU - Coverdale, James P.C.

AU - Kostrhunova, Hana

AU - Phillips, Roger

AU - Postings, Miles

AU - Shepherd, Samantha

AU - Scott, Peter

PY - 2020/6/14

Y1 - 2020/6/14

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AB - Functionalised triazole aldehydes are used in the highly selective self-assembly of water compatible, optically pure, low symmetry Fe(II)- and Zn(II)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.

KW - Metallosupramolecules

KW - Triazole

KW - Anticancer compounds

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JF - Chemical Communications

IS - 47

ER -

Triazole-based, optically-pure metallosupramolecules: highly potent and selective anticancer compounds

Abstract

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