Tribo-Electrification of Active Pharmaceutical Ingredients and Excipients

Enes Šupuk, Afsheen Zarrebini, Jay P. Reddy, Helen Hughes, Michael M. Leane, Mike J. Tobyn, Peter Timmins, Mojtaba Ghadiri

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Blending of active pharmaceutical ingredient (API) and excipients is a pre-requisite to the dry manufacture of solid dosage forms intended for oral use, whether or not granulation steps are employed prior to compaction. Excipients and API are known to be subject to tribo-electric charging, against each other and the materials in which the blends are manufactured (e.g. stainless steel 316). This study aimed to assess and compare the magnitude of tribo-electric charging of excipients and API using a material-sparing technique.Intra-sample variability in tribo-electric charging was found to be generally low. The results showed that excipients had lower charge levels and smaller variability as compared to the API materials. Some of the APIs tested charged extensively to the levels in excess of ±. 150. nC/g. It was also found that the extent of particle adhesion to surfaces of the container walls for charged API was considerably greater compared to the excipients. These results suggest that the extent and variability of tribo-electric charging of APIs is the predominant contributor to variability in electrostatic charge of pharmaceutical blends and to any related formulation issues. It is therefore reasonable to conclude that, to control the electrostatic properties of a formulation, it is a priority to control the particle properties of the API.

LanguageEnglish
Pages427-434
Number of pages8
JournalPowder Technology
Volume217
DOIs
Publication statusPublished - Feb 2012
Externally publishedYes

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Excipients
Drug products
Pharmaceutical Preparations
Application programming interfaces (API)
Electrostatics
Granulation
Stainless Steel
Dosage Forms
Containers
Compaction
Adhesion
Stainless steel

Cite this

Šupuk, E., Zarrebini, A., Reddy, J. P., Hughes, H., Leane, M. M., Tobyn, M. J., ... Ghadiri, M. (2012). Tribo-Electrification of Active Pharmaceutical Ingredients and Excipients. Powder Technology, 217, 427-434. https://doi.org/10.1016/j.powtec.2011.10.059
Šupuk, Enes ; Zarrebini, Afsheen ; Reddy, Jay P. ; Hughes, Helen ; Leane, Michael M. ; Tobyn, Mike J. ; Timmins, Peter ; Ghadiri, Mojtaba. / Tribo-Electrification of Active Pharmaceutical Ingredients and Excipients. In: Powder Technology. 2012 ; Vol. 217. pp. 427-434.
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Šupuk, E, Zarrebini, A, Reddy, JP, Hughes, H, Leane, MM, Tobyn, MJ, Timmins, P & Ghadiri, M 2012, 'Tribo-Electrification of Active Pharmaceutical Ingredients and Excipients', Powder Technology, vol. 217, pp. 427-434. https://doi.org/10.1016/j.powtec.2011.10.059

Tribo-Electrification of Active Pharmaceutical Ingredients and Excipients. / Šupuk, Enes; Zarrebini, Afsheen; Reddy, Jay P.; Hughes, Helen; Leane, Michael M.; Tobyn, Mike J.; Timmins, Peter; Ghadiri, Mojtaba.

In: Powder Technology, Vol. 217, 02.2012, p. 427-434.

Research output: Contribution to journalArticle

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AU - Zarrebini, Afsheen

AU - Reddy, Jay P.

AU - Hughes, Helen

AU - Leane, Michael M.

AU - Tobyn, Mike J.

AU - Timmins, Peter

AU - Ghadiri, Mojtaba

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