Triboelectrification and dissolution property enhancements of solid dispersions

Kofi Asare-Addo, Enes Šupuk, Hiba Al-Hamidi, Samuel Owusu-Ware, Ali Nokhodchi, Barbara R. Conway

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The use of solid dispersion techniques to modify physicochemical properties and improve solubility and dissolution rate may result in alteration to electrostatic properties of particles. Particle triboelectrification plays an important part in powder processing, affecting end product quality due to particle deposition and powder loss. This study investigates the use of glucosamine hydrochloride (GLU) in solid dispersions with indomethacin. Solvents selected for the preparation of the dispersions were acetone, acetone-water, ethanol and ethanol-water. Solid state characterizations (DSC, FTIR and XRPD) and dissolution were conducted. Dispersions were subjected to charge using a custom built device based on a shaking concept, consisting of a Faraday cup connected to an electrometer. All dispersions improved the dissolution rate of indomethacin. Analysis showed the method of preparation of the dispersion induced polymorphic forms of the drug. Indomethacin had a high propensity for charging (-411 nC/g). GLU had a very low charge (-1 nC/g). All dispersions had low charges (-1 to 14 nC/g). Acetone as a solvent, or in combination with water, produced samples with an electronegative charge in polarity. The same approach with ethanol produced electropositive charging. The results show the selection of solvents can influence powder charge thereby improving powder handling as well as dissolution properties.

Original languageEnglish
Pages (from-to)306-316
Number of pages11
JournalInternational Journal of Pharmaceutics
Volume485
Issue number1-2
DOIs
Publication statusPublished - 15 May 2015

Fingerprint

Powders
Acetone
Indomethacin
Ethanol
Glucosamine
Water
Fourier Transform Infrared Spectroscopy
Static Electricity
Solubility
Equipment and Supplies
Pharmaceutical Preparations

Cite this

@article{790001d7ed03419189de5f36421b81bb,
title = "Triboelectrification and dissolution property enhancements of solid dispersions",
abstract = "The use of solid dispersion techniques to modify physicochemical properties and improve solubility and dissolution rate may result in alteration to electrostatic properties of particles. Particle triboelectrification plays an important part in powder processing, affecting end product quality due to particle deposition and powder loss. This study investigates the use of glucosamine hydrochloride (GLU) in solid dispersions with indomethacin. Solvents selected for the preparation of the dispersions were acetone, acetone-water, ethanol and ethanol-water. Solid state characterizations (DSC, FTIR and XRPD) and dissolution were conducted. Dispersions were subjected to charge using a custom built device based on a shaking concept, consisting of a Faraday cup connected to an electrometer. All dispersions improved the dissolution rate of indomethacin. Analysis showed the method of preparation of the dispersion induced polymorphic forms of the drug. Indomethacin had a high propensity for charging (-411 nC/g). GLU had a very low charge (-1 nC/g). All dispersions had low charges (-1 to 14 nC/g). Acetone as a solvent, or in combination with water, produced samples with an electronegative charge in polarity. The same approach with ethanol produced electropositive charging. The results show the selection of solvents can influence powder charge thereby improving powder handling as well as dissolution properties.",
keywords = "Electrostatics, HCl, Indomethacin d-Glucosamine, Polymorphism, Solid dispersions, Triboelectrification",
author = "Kofi Asare-Addo and Enes Šupuk and Hiba Al-Hamidi and Samuel Owusu-Ware and Ali Nokhodchi and Conway, {Barbara R.}",
year = "2015",
month = "5",
day = "15",
doi = "10.1016/j.ijpharm.2015.03.013",
language = "English",
volume = "485",
pages = "306--316",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

Triboelectrification and dissolution property enhancements of solid dispersions. / Asare-Addo, Kofi; Šupuk, Enes; Al-Hamidi, Hiba; Owusu-Ware, Samuel; Nokhodchi, Ali; Conway, Barbara R.

In: International Journal of Pharmaceutics, Vol. 485, No. 1-2, 15.05.2015, p. 306-316.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Triboelectrification and dissolution property enhancements of solid dispersions

AU - Asare-Addo, Kofi

AU - Šupuk, Enes

AU - Al-Hamidi, Hiba

AU - Owusu-Ware, Samuel

AU - Nokhodchi, Ali

AU - Conway, Barbara R.

PY - 2015/5/15

Y1 - 2015/5/15

N2 - The use of solid dispersion techniques to modify physicochemical properties and improve solubility and dissolution rate may result in alteration to electrostatic properties of particles. Particle triboelectrification plays an important part in powder processing, affecting end product quality due to particle deposition and powder loss. This study investigates the use of glucosamine hydrochloride (GLU) in solid dispersions with indomethacin. Solvents selected for the preparation of the dispersions were acetone, acetone-water, ethanol and ethanol-water. Solid state characterizations (DSC, FTIR and XRPD) and dissolution were conducted. Dispersions were subjected to charge using a custom built device based on a shaking concept, consisting of a Faraday cup connected to an electrometer. All dispersions improved the dissolution rate of indomethacin. Analysis showed the method of preparation of the dispersion induced polymorphic forms of the drug. Indomethacin had a high propensity for charging (-411 nC/g). GLU had a very low charge (-1 nC/g). All dispersions had low charges (-1 to 14 nC/g). Acetone as a solvent, or in combination with water, produced samples with an electronegative charge in polarity. The same approach with ethanol produced electropositive charging. The results show the selection of solvents can influence powder charge thereby improving powder handling as well as dissolution properties.

AB - The use of solid dispersion techniques to modify physicochemical properties and improve solubility and dissolution rate may result in alteration to electrostatic properties of particles. Particle triboelectrification plays an important part in powder processing, affecting end product quality due to particle deposition and powder loss. This study investigates the use of glucosamine hydrochloride (GLU) in solid dispersions with indomethacin. Solvents selected for the preparation of the dispersions were acetone, acetone-water, ethanol and ethanol-water. Solid state characterizations (DSC, FTIR and XRPD) and dissolution were conducted. Dispersions were subjected to charge using a custom built device based on a shaking concept, consisting of a Faraday cup connected to an electrometer. All dispersions improved the dissolution rate of indomethacin. Analysis showed the method of preparation of the dispersion induced polymorphic forms of the drug. Indomethacin had a high propensity for charging (-411 nC/g). GLU had a very low charge (-1 nC/g). All dispersions had low charges (-1 to 14 nC/g). Acetone as a solvent, or in combination with water, produced samples with an electronegative charge in polarity. The same approach with ethanol produced electropositive charging. The results show the selection of solvents can influence powder charge thereby improving powder handling as well as dissolution properties.

KW - Electrostatics

KW - HCl

KW - Indomethacin d-Glucosamine

KW - Polymorphism

KW - Solid dispersions

KW - Triboelectrification

UR - http://www.scopus.com/inward/record.url?scp=84925353368&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2015.03.013

DO - 10.1016/j.ijpharm.2015.03.013

M3 - Article

VL - 485

SP - 306

EP - 316

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -