Unconventional Methyl Galactan Synthesized via the Thexyldimethylsilyl Intermediate

Preparation, Characterization, and Properties

Andreas Koschella, Kari Inngjerdingen, Berit S. Paulsen, Gordon A. Morris, Stephen E. Harding, Thomas Heinze

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Reaction of a β-(1 → 4) linked galactan with TDMS chloride followed by methylation and desilylation yields methyl galactans with unconventional functionalization patterns. The products were characterized via FTIR and NMR of the intact polymer and by CE after controlled depolymerization. A TDMS-derivatized methyl galactan contains differently methylated secondary hydroxyl groups. SEC and analytical ultracentrifugation showed a consistent decrease in the molecular weight after the consecutive reaction steps. Biological studies revealed that the methyl galactans are less active in complement fixation assays as compared with a 3-O-methyl galactan-enriched polysaccharide fraction isolated from Acanthus ebracteatus. (Graph Presented)

Original languageEnglish
Pages (from-to)96-105
Number of pages10
JournalMacromolecular Bioscience
Volume8
Issue number1
Early online date28 Sep 2007
DOIs
Publication statusPublished - 9 Jan 2008
Externally publishedYes

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Galactans
Acanthaceae
Depolymerization
Methylation
Ultracentrifugation
Fourier Transform Infrared Spectroscopy
Polysaccharides
Hydroxyl Radical
Chlorides
Assays
Polymers
Molecular Weight
Molecular weight
Nuclear magnetic resonance

Cite this

Koschella, Andreas ; Inngjerdingen, Kari ; Paulsen, Berit S. ; Morris, Gordon A. ; Harding, Stephen E. ; Heinze, Thomas. / Unconventional Methyl Galactan Synthesized via the Thexyldimethylsilyl Intermediate : Preparation, Characterization, and Properties. In: Macromolecular Bioscience. 2008 ; Vol. 8, No. 1. pp. 96-105.
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Unconventional Methyl Galactan Synthesized via the Thexyldimethylsilyl Intermediate : Preparation, Characterization, and Properties. / Koschella, Andreas; Inngjerdingen, Kari; Paulsen, Berit S.; Morris, Gordon A.; Harding, Stephen E.; Heinze, Thomas.

In: Macromolecular Bioscience, Vol. 8, No. 1, 09.01.2008, p. 96-105.

Research output: Contribution to journalArticle

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