Understanding Magnetite Biomineralisation: The Effect of Short Amino Acid Sequences on the {100} and the {111} Surface

Amy E. Monnington, David J. Cooke

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Magnetite (Fe3O4) formation within Magnetospirillum magneticum strain AMB-1 occurs under the influence of the Mms6 protein. It is hypothesised that if key iron binding sites within the C-terminus of the Mms6 protein are substituted for alanine, the protein's overall iron binding ability is diminished. In this study, an atomistic model of Mms6-driven magnetite formation was developed and the attachment of series amino acid repeats (alanine-alanine, alanine-glutamic acid & glutamic acid-glutamic acid) to the {100} & {111} magnetite surfaces were investigated. Our results suggest the substitution of glutamic acid for alanine residues significantly reduces iron binding affinity of the system, thus confirming the hypothesis. In addition, it is shown that the surface of preferable attachment is the {111} magnetite surface.

Original languageEnglish
Title of host publicationBiomimetic, Bio-inspired and Self-Assembled Materials for Engineered Surfaces and Applications
EditorsMichelle L. Oyen, Shelly R. Peyton, Gila E. Stein
PublisherMaterials Research Society
Pages239-245
Number of pages7
Volume1498
ISBN (Print)9781605114750, 1605114758
DOIs
Publication statusPublished - 2013
Event2012 MRS Fall Meeting - Boston, United States
Duration: 25 Nov 201230 Nov 2012
https://www.mrs.org/fall2012

Publication series

NameMaterials Research Society Symposium Proceedings
PublisherMaterials Research Society
Volume1498
ISSN (Print)0272-9172

Conference

Conference2012 MRS Fall Meeting
CountryUnited States
CityBoston
Period25/11/1230/11/12
Internet address

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  • Cite this

    Monnington, A. E., & Cooke, D. J. (2013). Understanding Magnetite Biomineralisation: The Effect of Short Amino Acid Sequences on the {100} and the {111} Surface. In M. L. Oyen, S. R. Peyton, & G. E. Stein (Eds.), Biomimetic, Bio-inspired and Self-Assembled Materials for Engineered Surfaces and Applications (Vol. 1498, pp. 239-245). (Materials Research Society Symposium Proceedings; Vol. 1498). Materials Research Society. https://doi.org/10.1557/opl.2013.343