Unusual loss of chymosin in mammalian lineages parallels neo-natal immune transfer strategies

Mónica Lopes-Marques, Raquel Ruivo, Elza Fonseca, Ana Andreia Mendes Teixeira, L. Filipe C. Castro

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Gene duplication and loss are powerful drivers of evolutionary change. The role of loss in phenotypic diversification is notably illustrated by the variable enzymatic repertoire involved in vertebrate protein digestion. Among these we find the pepsin family of aspartic proteinases, including chymosin (Cmy). Previous studies demonstrated that Cmy, a neo-natal digestive pepsin, is inactivated in some primates, including humans. This pseudogenization event was hypothesized to result from the acquisition of maternal immune immunoglobulin G (IgG) transfer. By investigating 94 mammalian subgenomes we reveal an unprecedented level of Cmy erosion in placental mammals, with numerous independent events of gene loss taking place in Primates, Dermoptera, Rodentia, Cetacea and Perissodactyla. Our findings strongly suggest that the recurrent inactivation of Cmy correlates with the evolution of the passive transfer of IgG and uncovers a noteworthy case of evolutionary cross-talk between the digestive and the immune system, modulated by gene loss.
Original languageEnglish
Pages (from-to)78-86
Number of pages9
JournalMolecular Phylogenetics and Evolution
Volume116
Early online date26 Aug 2017
DOIs
Publication statusPublished - 1 Nov 2017
Externally publishedYes

Fingerprint

Chymosin
chymosin
Pepsin A
immunoglobulin G
pepsin
Primates
Perissodactyla
Cetacea
Immunoglobulin G
Aspartic Acid Proteases
aspartic proteinases
Digestive System
Gene Duplication
gene duplication
Rodentia
primate
Proteolysis
Genes
immune system
Vertebrates

Cite this

Lopes-Marques, Mónica ; Ruivo, Raquel ; Fonseca, Elza ; Mendes Teixeira, Ana Andreia ; Castro, L. Filipe C. / Unusual loss of chymosin in mammalian lineages parallels neo-natal immune transfer strategies. In: Molecular Phylogenetics and Evolution. 2017 ; Vol. 116. pp. 78-86.
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Unusual loss of chymosin in mammalian lineages parallels neo-natal immune transfer strategies. / Lopes-Marques, Mónica; Ruivo, Raquel; Fonseca, Elza; Mendes Teixeira, Ana Andreia; Castro, L. Filipe C.

In: Molecular Phylogenetics and Evolution, Vol. 116, 01.11.2017, p. 78-86.

Research output: Contribution to journalArticle

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AU - Lopes-Marques, Mónica

AU - Ruivo, Raquel

AU - Fonseca, Elza

AU - Mendes Teixeira, Ana Andreia

AU - Castro, L. Filipe C.

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