Unusual macrocyclic spirocycles from tandem metathesis reactions

Robert A.J. Wybrow, Leigh A. Johnson, Benoit Auffray, Wesley J. Moran, Harry Adams, Joseph P.A. Harrity

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


This letter details the formation of 18-membered macrocyclic spirocyclic esters and ethers from readily prepared tetraene precursors via tandem metathesis reactions. Factors which control the course of these transition metal catalysed processes are discussed and the crystal structures of the novel macrocycles obtained are delineated.

Original languageEnglish
Pages (from-to)7851-7854
Number of pages4
JournalTetrahedron Letters
Issue number44
Early online date3 Oct 2002
Publication statusPublished - 28 Oct 2002
Externally publishedYes


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