TY - JOUR
T1 - Use of Potentially Inappropriate Medications in People With Dementia in Vietnam and Its Associated Factors
AU - Nguyen, Tuan Anh
AU - Pham, Thang
AU - Vu, Huyen Thi Thanh
AU - Nguyen, Thanh Xuan
AU - Vu, Trinh Thi
AU - Nguyen, Binh Thi Thanh
AU - Nguyen, Ngoc Quynh
AU - Nguyen, Binh Thanh
AU - Nguyen, Binh Thanh
AU - Nguyen, Tam Ngoc
AU - Phan, Sinh Viet
AU - Nguyen, Anh Trung
AU - Pham, Tuan Le
AU - Dang, Ha Thu
AU - Kalisch-Ellett, Lisa
AU - Gillam, Marianne
AU - Pratt, Nicole
AU - Qiang, Sun
AU - Wang, Haipeng
AU - Kanjanarach, Tipaporn
AU - Hassali, Mohamed Azmi Ahmad
AU - Babar, Zaheer-Ud-Din
AU - Razak, Asrenee Ab
AU - Chinwong, Dujrudee
AU - Roughead, Elizabeth E.
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the China-Australia Centre for Health Sciences Research seed funding grant (T.A.N, S.Q, E.E.R, L.K.E, M.G, and H.W). T.A.N and L.K.E are the recipients of an Australian NHMRC-ARC Dementia Research Development Fellowship (T.A.N Grant identification number APP1103860; L.K.E Grant identification number APP1101788). E.E.R is supported by an NHMRC Senior Principal Research Fellowship (Grant identification number APP1110139). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© The Author(s) 2018.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - This study examined the use of potentially inappropriate medicines that may affect cognition (PIMcog) in people with dementia and its associated factors. Medical records of all outpatients with dementia attending a tertiary hospital in Vietnam between January 1, 2015, and December 31, 2016, were examined. Medicine use was assessed against a list of PIMcog. Variables associated with having a PIMcog were assessed using a multiple logistic regression. Of the 128 patients, 41% used a PIMcog, 39.1% used cholinesterase inhibitors (CEIs) concomitantly with anticholinergics, and 18% used antipsychotics. The number of hospital visits (adjusted odds ratio [OR]: 1.08; 95% confidence interval [CI]: 1.02-1.16) and number of treating specialists (adjusted OR: 0.61; 95% CI: 0.45-0.83) were associated with PIMcog use. This study highlights a high-level use of medicines that can further impair cognition or reduce the effectiveness of CEIs in people with dementia. Efforts to improve quality use of medicines for this population are warranted.
AB - This study examined the use of potentially inappropriate medicines that may affect cognition (PIMcog) in people with dementia and its associated factors. Medical records of all outpatients with dementia attending a tertiary hospital in Vietnam between January 1, 2015, and December 31, 2016, were examined. Medicine use was assessed against a list of PIMcog. Variables associated with having a PIMcog were assessed using a multiple logistic regression. Of the 128 patients, 41% used a PIMcog, 39.1% used cholinesterase inhibitors (CEIs) concomitantly with anticholinergics, and 18% used antipsychotics. The number of hospital visits (adjusted odds ratio [OR]: 1.08; 95% confidence interval [CI]: 1.02-1.16) and number of treating specialists (adjusted OR: 0.61; 95% CI: 0.45-0.83) were associated with PIMcog use. This study highlights a high-level use of medicines that can further impair cognition or reduce the effectiveness of CEIs in people with dementia. Efforts to improve quality use of medicines for this population are warranted.
KW - anticholinergics
KW - antipsychotics
KW - dementia
KW - potentially inappropriate medicines
KW - quality use of medicines
KW - sedatives
UR - http://www.scopus.com/inward/record.url?scp=85045271531&partnerID=8YFLogxK
U2 - 10.1177/1533317518768999
DO - 10.1177/1533317518768999
M3 - Article
AN - SCOPUS:85045271531
VL - 33
SP - 423
EP - 432
JO - American Journal of Alzheimer's Disease and other Dementias
JF - American Journal of Alzheimer's Disease and other Dementias
SN - 1533-3175
IS - 7
ER -
