Use of Potentially Inappropriate Medications in People With Dementia in Vietnam and Its Associated Factors

Tuan Anh Nguyen, Thang Pham, Huyen Thi Thanh Vu, Thanh Xuan Nguyen, Trinh Thi Vu, Binh Thi Thanh Nguyen, Ngoc Quynh Nguyen, Binh Thanh Nguyen, Binh Thanh Nguyen, Tam Ngoc Nguyen, Sinh Viet Phan, Anh Trung Nguyen, Tuan Le Pham, Ha Thu Dang, Lisa Kalisch-Ellett, Marianne Gillam, Nicole Pratt, Sun Qiang, Haipeng Wang, Tipaporn Kanjanarach & 5 others Mohamed Azmi Ahmad Hassali, Zaheer-Ud-Din Babar, Asrenee Ab Razak, Dujrudee Chinwong, Elizabeth E. Roughead

Research output: Contribution to journalArticle

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Abstract

This study examined the use of potentially inappropriate medicines that may affect cognition (PIMcog) in people with dementia and its associated factors. Medical records of all outpatients with dementia attending a tertiary hospital in Vietnam between January 1, 2015, and December 31, 2016, were examined. Medicine use was assessed against a list of PIMcog. Variables associated with having a PIMcog were assessed using a multiple logistic regression. Of the 128 patients, 41% used a PIMcog, 39.1% used cholinesterase inhibitors (CEIs) concomitantly with anticholinergics, and 18% used antipsychotics. The number of hospital visits (adjusted odds ratio [OR]: 1.08; 95% confidence interval [CI]: 1.02-1.16) and number of treating specialists (adjusted OR: 0.61; 95% CI: 0.45-0.83) were associated with PIMcog use. This study highlights a high-level use of medicines that can further impair cognition or reduce the effectiveness of CEIs in people with dementia. Efforts to improve quality use of medicines for this population are warranted.

Original languageEnglish
Pages (from-to)423-432
Number of pages10
JournalAmerican Journal of Alzheimer's Disease and other Dementias
Volume33
Issue number7
Early online date11 Apr 2018
DOIs
Publication statusPublished - 1 Nov 2018

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Vietnam
Dementia
Cholinesterase Inhibitors
Cognition
Odds Ratio
Confidence Intervals
Cholinergic Antagonists
Tertiary Care Centers
Antipsychotic Agents
Medical Records
Outpatients
Logistic Models
Medicine
Population
Potentially Inappropriate Medication List

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Nguyen, Tuan Anh ; Pham, Thang ; Vu, Huyen Thi Thanh ; Nguyen, Thanh Xuan ; Vu, Trinh Thi ; Nguyen, Binh Thi Thanh ; Nguyen, Ngoc Quynh ; Nguyen, Binh Thanh ; Nguyen, Binh Thanh ; Nguyen, Tam Ngoc ; Phan, Sinh Viet ; Nguyen, Anh Trung ; Pham, Tuan Le ; Dang, Ha Thu ; Kalisch-Ellett, Lisa ; Gillam, Marianne ; Pratt, Nicole ; Qiang, Sun ; Wang, Haipeng ; Kanjanarach, Tipaporn ; Hassali, Mohamed Azmi Ahmad ; Babar, Zaheer-Ud-Din ; Razak, Asrenee Ab ; Chinwong, Dujrudee ; Roughead, Elizabeth E. / Use of Potentially Inappropriate Medications in People With Dementia in Vietnam and Its Associated Factors. In: American Journal of Alzheimer's Disease and other Dementias. 2018 ; Vol. 33, No. 7. pp. 423-432.
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Nguyen, TA, Pham, T, Vu, HTT, Nguyen, TX, Vu, TT, Nguyen, BTT, Nguyen, NQ, Nguyen, BT, Nguyen, BT, Nguyen, TN, Phan, SV, Nguyen, AT, Pham, TL, Dang, HT, Kalisch-Ellett, L, Gillam, M, Pratt, N, Qiang, S, Wang, H, Kanjanarach, T, Hassali, MAA, Babar, Z-U-D, Razak, AA, Chinwong, D & Roughead, EE 2018, 'Use of Potentially Inappropriate Medications in People With Dementia in Vietnam and Its Associated Factors', American Journal of Alzheimer's Disease and other Dementias, vol. 33, no. 7, pp. 423-432. https://doi.org/10.1177/1533317518768999

Use of Potentially Inappropriate Medications in People With Dementia in Vietnam and Its Associated Factors. / Nguyen, Tuan Anh; Pham, Thang; Vu, Huyen Thi Thanh; Nguyen, Thanh Xuan; Vu, Trinh Thi; Nguyen, Binh Thi Thanh; Nguyen, Ngoc Quynh; Nguyen, Binh Thanh; Nguyen, Binh Thanh; Nguyen, Tam Ngoc; Phan, Sinh Viet; Nguyen, Anh Trung; Pham, Tuan Le; Dang, Ha Thu; Kalisch-Ellett, Lisa; Gillam, Marianne; Pratt, Nicole; Qiang, Sun; Wang, Haipeng; Kanjanarach, Tipaporn; Hassali, Mohamed Azmi Ahmad; Babar, Zaheer-Ud-Din; Razak, Asrenee Ab; Chinwong, Dujrudee; Roughead, Elizabeth E.

In: American Journal of Alzheimer's Disease and other Dementias, Vol. 33, No. 7, 01.11.2018, p. 423-432.

Research output: Contribution to journalArticle

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