Use of sulforaphane in COVID-19: Clinical trials are needed

Chia Siang Kow; Dinesh Sangarran Ramachandram; Syed Shahzad Hasan

doi:10.1016/j.molimm.2022.03.001

Use of sulforaphane in COVID-19: Clinical trials are needed

Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan

Research output: Contribution to journal › Letter › peer-review

6 Citations (Scopus)

Abstract

We read with interest the narrative review authored by Kiser et al. (2021), which discussed extensively the antioxidant effect and anti-inflammatory effect of sulforaphane, a dietary supplement found in high amounts in cruciferous vegetables that is orally accessible and well-tolerated. Notably, in their review, the authors also discussed the potential use of sulforaphane in patients with coronavirus disease 2019 (COVID-19). Sulforaphane mediates the inhibitory effect on NLRP3 inflammasome activation and we believe that this could be the main mechanism where sulforaphane is useful for patients with COVID-19.

Original language	English
Pages (from-to)	78-79
Number of pages	2
Journal	Molecular Immunology
Volume	145
Early online date	15 Mar 2022
DOIs	https://doi.org/10.1016/j.molimm.2022.03.001
Publication status	Published - 1 May 2022

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title = "Use of sulforaphane in COVID-19: Clinical trials are needed",

abstract = "We read with interest the narrative review authored by Kiser et al. (2021), which discussed extensively the antioxidant effect and anti-inflammatory effect of sulforaphane, a dietary supplement found in high amounts in cruciferous vegetables that is orally accessible and well-tolerated. Notably, in their review, the authors also discussed the potential use of sulforaphane in patients with coronavirus disease 2019 (COVID-19). Sulforaphane mediates the inhibitory effect on NLRP3 inflammasome activation and we believe that this could be the main mechanism where sulforaphane is useful for patients with COVID-19.",

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T2 - Clinical trials are needed

AU - Kow, Chia Siang

AU - Ramachandram, Dinesh Sangarran

AU - Hasan, Syed Shahzad

PY - 2022/5/1

Y1 - 2022/5/1

N2 - We read with interest the narrative review authored by Kiser et al. (2021), which discussed extensively the antioxidant effect and anti-inflammatory effect of sulforaphane, a dietary supplement found in high amounts in cruciferous vegetables that is orally accessible and well-tolerated. Notably, in their review, the authors also discussed the potential use of sulforaphane in patients with coronavirus disease 2019 (COVID-19). Sulforaphane mediates the inhibitory effect on NLRP3 inflammasome activation and we believe that this could be the main mechanism where sulforaphane is useful for patients with COVID-19.

AB - We read with interest the narrative review authored by Kiser et al. (2021), which discussed extensively the antioxidant effect and anti-inflammatory effect of sulforaphane, a dietary supplement found in high amounts in cruciferous vegetables that is orally accessible and well-tolerated. Notably, in their review, the authors also discussed the potential use of sulforaphane in patients with coronavirus disease 2019 (COVID-19). Sulforaphane mediates the inhibitory effect on NLRP3 inflammasome activation and we believe that this could be the main mechanism where sulforaphane is useful for patients with COVID-19.

KW - sulforaphane

KW - COVID-19

KW - clinical trial

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EP - 79

JO - Molecular Immunology

JF - Molecular Immunology

SN - 0161-5890

ER -

Use of sulforaphane in COVID-19: Clinical trials are needed

Abstract

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