TY - JOUR
T1 - Use of thermodynamics in understanding drug release from xanthan gum matrices
T2 - The influence of clay-drug complexes
AU - Totea, Ana-Maria
AU - Dorin, Irina
AU - Laity, Peter
AU - Conway, Barbara
AU - Waters, Laura
AU - Asare-Addo, Kofi
N1 - Funding Information:
Ana-Maria Totea and the authors thank the University of Huddersfield for funding.
Publisher Copyright:
© 2020
PY - 2020/12/25
Y1 - 2020/12/25
N2 - The aim of this study was to outline a novel way of understanding the controlled drug release from drug-clay-polymer matrices using isothermal calorimetry (ITC) as a complementary technique to dissolution studies. ITC results showed that the binding phenomenon between the model drug propranolol hydrochloride (PPN) and magnesium aluminium silicate (MAS) in the presence of xanthan gum (XG was spontaneous and enthalpically driven (negative enthalpy (ΔH) and small entropy (-T∆S)). This may be due to the competition for PPN due to the anionic nature of XG. Dissolution results showed that when using the MAS-PPN complexes, 10 % w/w XG polymer level was enough to significantly reduce the burst release. When used together, ITC and dissolution studies may help a formulator understand and identify interactions which occur during dissolution studies and may be beneficial to the controlled drug delivery system.
AB - The aim of this study was to outline a novel way of understanding the controlled drug release from drug-clay-polymer matrices using isothermal calorimetry (ITC) as a complementary technique to dissolution studies. ITC results showed that the binding phenomenon between the model drug propranolol hydrochloride (PPN) and magnesium aluminium silicate (MAS) in the presence of xanthan gum (XG was spontaneous and enthalpically driven (negative enthalpy (ΔH) and small entropy (-T∆S)). This may be due to the competition for PPN due to the anionic nature of XG. Dissolution results showed that when using the MAS-PPN complexes, 10 % w/w XG polymer level was enough to significantly reduce the burst release. When used together, ITC and dissolution studies may help a formulator understand and identify interactions which occur during dissolution studies and may be beneficial to the controlled drug delivery system.
KW - Complexation
KW - Isothermal titration calorimetry
KW - Magnesium aluminium silicate
KW - Propranolol hydrochloride
KW - Xanthan gum
UR - http://www.scopus.com/inward/record.url?scp=85125660841&partnerID=8YFLogxK
U2 - 10.1016/j.carpta.2020.100012
DO - 10.1016/j.carpta.2020.100012
M3 - Article
VL - 1
JO - Carbohydrate Polymer Technologies and Applications
JF - Carbohydrate Polymer Technologies and Applications
SN - 2666-8939
M1 - 100012
ER -
