Utility Elicitation for Allergic Rhinoconjunctivitis and Asthma in Children

Ts Grand, J Retzler, Ab Smith, Rm Romano, A Domdey

Research output: Contribution to journalMeeting Abstract

Abstract

Objectives
This study aimed to generate utility and disutility values for seasonal allergic rhinoconjunctivitis (ARC) and asthma in children, in order to demonstrate the impact of these conditions on patients' health-related quality of life.

Methods
Health state descriptions were developed using clinical guidelines, Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Initiative for Asthma (GINA) to incorporate symptoms, impact on daily life, as well as treatments required. Descriptions were amended with clinician and patient input, and adapted for lower reading ages. An online survey presented respondents with the health state descriptions in a randomised order. After each description, respondents rated the health state using a visual analogue scale (VAS). The survey was distributed to children aged 8 to 11 from four European countries (UK, France, Germany, Slovakia) via consenting parents recruited by a third party panel company. Average utility and disutility values were calculated.

Results
1082 respondents completed the survey. Except for severe ARC, respondents who reported experience with ARC (55.1%) and asthma (23.8%) provided similar utility values as respondents that did not report these experiences. Average utility values reported for each health state were: mild ARC 0.705, moderate ARC 0.675, severe ARC 0.666, mild ARC with well-to-partly controlled asthma (WPCA) 0.677, moderate ARC with WPCA 0.668 and severe ARC with WPCA 0.663. Average disutility for increased severity from mild to moderate ARC was -0.131, from mild to severe ARC was -0.121, and from moderate to severe ARC was -0.101. Disutilities for comorbid WPCA in addition to mild, moderate and severe ARC were -0.089, -0.098 and -0.094, respectively.

Conclusions
More severe health states resulted in lower utility values. Disutility values were highest for changes between the mildest and most severe health states. ARC with and without WPCA has considerable negative impact on quality of life in children.
LanguageEnglish
PagesA648
Number of pages1
JournalValue in Health
Volume20
Issue number9
DOIs
Publication statusPublished - 1 Oct 2017
Externally publishedYes

Fingerprint

Asthma
Health
Quality of Life
Slovakia
Surveys and Questionnaires
Visual Analog Scale
France
Germany
Reading
Parents
Guidelines

Cite this

Grand, Ts ; Retzler, J ; Smith, Ab ; Romano, Rm ; Domdey, A. / Utility Elicitation for Allergic Rhinoconjunctivitis and Asthma in Children. In: Value in Health. 2017 ; Vol. 20, No. 9. pp. A648.
@article{18689d0e9039433d906a72abc731622b,
title = "Utility Elicitation for Allergic Rhinoconjunctivitis and Asthma in Children",
abstract = "ObjectivesThis study aimed to generate utility and disutility values for seasonal allergic rhinoconjunctivitis (ARC) and asthma in children, in order to demonstrate the impact of these conditions on patients' health-related quality of life.MethodsHealth state descriptions were developed using clinical guidelines, Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Initiative for Asthma (GINA) to incorporate symptoms, impact on daily life, as well as treatments required. Descriptions were amended with clinician and patient input, and adapted for lower reading ages. An online survey presented respondents with the health state descriptions in a randomised order. After each description, respondents rated the health state using a visual analogue scale (VAS). The survey was distributed to children aged 8 to 11 from four European countries (UK, France, Germany, Slovakia) via consenting parents recruited by a third party panel company. Average utility and disutility values were calculated.Results1082 respondents completed the survey. Except for severe ARC, respondents who reported experience with ARC (55.1{\%}) and asthma (23.8{\%}) provided similar utility values as respondents that did not report these experiences. Average utility values reported for each health state were: mild ARC 0.705, moderate ARC 0.675, severe ARC 0.666, mild ARC with well-to-partly controlled asthma (WPCA) 0.677, moderate ARC with WPCA 0.668 and severe ARC with WPCA 0.663. Average disutility for increased severity from mild to moderate ARC was -0.131, from mild to severe ARC was -0.121, and from moderate to severe ARC was -0.101. Disutilities for comorbid WPCA in addition to mild, moderate and severe ARC were -0.089, -0.098 and -0.094, respectively.ConclusionsMore severe health states resulted in lower utility values. Disutility values were highest for changes between the mildest and most severe health states. ARC with and without WPCA has considerable negative impact on quality of life in children.",
author = "Ts Grand and J Retzler and Ab Smith and Rm Romano and A Domdey",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.jval.2017.08.1505",
language = "English",
volume = "20",
pages = "A648",
journal = "Value in Health",
issn = "1098-3015",
publisher = "Elsevier Limited",
number = "9",

}

Utility Elicitation for Allergic Rhinoconjunctivitis and Asthma in Children. / Grand, Ts; Retzler, J; Smith, Ab; Romano, Rm; Domdey, A.

In: Value in Health, Vol. 20, No. 9, 01.10.2017, p. A648.

Research output: Contribution to journalMeeting Abstract

TY - JOUR

T1 - Utility Elicitation for Allergic Rhinoconjunctivitis and Asthma in Children

AU - Grand, Ts

AU - Retzler, J

AU - Smith, Ab

AU - Romano, Rm

AU - Domdey, A

PY - 2017/10/1

Y1 - 2017/10/1

N2 - ObjectivesThis study aimed to generate utility and disutility values for seasonal allergic rhinoconjunctivitis (ARC) and asthma in children, in order to demonstrate the impact of these conditions on patients' health-related quality of life.MethodsHealth state descriptions were developed using clinical guidelines, Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Initiative for Asthma (GINA) to incorporate symptoms, impact on daily life, as well as treatments required. Descriptions were amended with clinician and patient input, and adapted for lower reading ages. An online survey presented respondents with the health state descriptions in a randomised order. After each description, respondents rated the health state using a visual analogue scale (VAS). The survey was distributed to children aged 8 to 11 from four European countries (UK, France, Germany, Slovakia) via consenting parents recruited by a third party panel company. Average utility and disutility values were calculated.Results1082 respondents completed the survey. Except for severe ARC, respondents who reported experience with ARC (55.1%) and asthma (23.8%) provided similar utility values as respondents that did not report these experiences. Average utility values reported for each health state were: mild ARC 0.705, moderate ARC 0.675, severe ARC 0.666, mild ARC with well-to-partly controlled asthma (WPCA) 0.677, moderate ARC with WPCA 0.668 and severe ARC with WPCA 0.663. Average disutility for increased severity from mild to moderate ARC was -0.131, from mild to severe ARC was -0.121, and from moderate to severe ARC was -0.101. Disutilities for comorbid WPCA in addition to mild, moderate and severe ARC were -0.089, -0.098 and -0.094, respectively.ConclusionsMore severe health states resulted in lower utility values. Disutility values were highest for changes between the mildest and most severe health states. ARC with and without WPCA has considerable negative impact on quality of life in children.

AB - ObjectivesThis study aimed to generate utility and disutility values for seasonal allergic rhinoconjunctivitis (ARC) and asthma in children, in order to demonstrate the impact of these conditions on patients' health-related quality of life.MethodsHealth state descriptions were developed using clinical guidelines, Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Initiative for Asthma (GINA) to incorporate symptoms, impact on daily life, as well as treatments required. Descriptions were amended with clinician and patient input, and adapted for lower reading ages. An online survey presented respondents with the health state descriptions in a randomised order. After each description, respondents rated the health state using a visual analogue scale (VAS). The survey was distributed to children aged 8 to 11 from four European countries (UK, France, Germany, Slovakia) via consenting parents recruited by a third party panel company. Average utility and disutility values were calculated.Results1082 respondents completed the survey. Except for severe ARC, respondents who reported experience with ARC (55.1%) and asthma (23.8%) provided similar utility values as respondents that did not report these experiences. Average utility values reported for each health state were: mild ARC 0.705, moderate ARC 0.675, severe ARC 0.666, mild ARC with well-to-partly controlled asthma (WPCA) 0.677, moderate ARC with WPCA 0.668 and severe ARC with WPCA 0.663. Average disutility for increased severity from mild to moderate ARC was -0.131, from mild to severe ARC was -0.121, and from moderate to severe ARC was -0.101. Disutilities for comorbid WPCA in addition to mild, moderate and severe ARC were -0.089, -0.098 and -0.094, respectively.ConclusionsMore severe health states resulted in lower utility values. Disutility values were highest for changes between the mildest and most severe health states. ARC with and without WPCA has considerable negative impact on quality of life in children.

U2 - 10.1016/j.jval.2017.08.1505

DO - 10.1016/j.jval.2017.08.1505

M3 - Meeting Abstract

VL - 20

SP - A648

JO - Value in Health

T2 - Value in Health

JF - Value in Health

SN - 1098-3015

IS - 9

ER -