TY - JOUR
T1 - Voltage-dependent anion channels
T2 - The wizard of the mitochondrial outer membrane
AU - Mertins, Barbara
AU - Psakis, Georgios
AU - Essen, Lars Oliver
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains elusive. Here we review recent progress in terms of VDACs' structure and regulation, with a special focus on the molecular aspects of gating and the interaction with effector proteins.
AB - Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains elusive. Here we review recent progress in terms of VDACs' structure and regulation, with a special focus on the molecular aspects of gating and the interaction with effector proteins.
KW - Eukaryotic porin structure
KW - Intrinsic apoptotic pathway
KW - Ion-channel gating
KW - Membrane protein phylogeny
KW - Structural plasticity
KW - κ-barrel topology
UR - http://www.scopus.com/inward/record.url?scp=84925854108&partnerID=8YFLogxK
U2 - 10.1515/hsz-2014-0203
DO - 10.1515/hsz-2014-0203
M3 - Article
C2 - 25153596
AN - SCOPUS:84925854108
VL - 395
SP - 1435
EP - 1442
JO - Biological Chemistry
JF - Biological Chemistry
SN - 1431-6730
IS - 12
ER -