Voltage-dependent anion channels: The wizard of the mitochondrial outer membrane

Barbara Mertins, Georgios Psakis, Lars Oliver Essen

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains elusive. Here we review recent progress in terms of VDACs' structure and regulation, with a special focus on the molecular aspects of gating and the interaction with effector proteins.

Original languageEnglish
Pages (from-to)1435-1442
Number of pages8
JournalBiological Chemistry
Volume395
Issue number12
DOIs
Publication statusPublished - 1 Dec 2014

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