Voltage-dependent anion channels: The wizard of the mitochondrial outer membrane

Barbara Mertins; Georgios Psakis; Lars Oliver Essen

doi:10.1515/hsz-2014-0203

Voltage-dependent anion channels: The wizard of the mitochondrial outer membrane

Barbara Mertins, Georgios Psakis, Lars Oliver Essen

Philipps-University Marburg

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains elusive. Here we review recent progress in terms of VDACs' structure and regulation, with a special focus on the molecular aspects of gating and the interaction with effector proteins.

Original language	English
Pages (from-to)	1435-1442
Number of pages	8
Journal	Biological Chemistry
Volume	395
Issue number	12
Early online date	20 Aug 2014
DOIs	https://doi.org/10.1515/hsz-2014-0203
Publication status	Published - 1 Dec 2014

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abstract = "Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains elusive. Here we review recent progress in terms of VDACs' structure and regulation, with a special focus on the molecular aspects of gating and the interaction with effector proteins.",

keywords = "Eukaryotic porin structure, Intrinsic apoptotic pathway, Ion-channel gating, Membrane protein phylogeny, Structural plasticity, κ-barrel topology",

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AU - Essen, Lars Oliver

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Y1 - 2014/12/1

N2 - Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains elusive. Here we review recent progress in terms of VDACs' structure and regulation, with a special focus on the molecular aspects of gating and the interaction with effector proteins.

AB - Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains elusive. Here we review recent progress in terms of VDACs' structure and regulation, with a special focus on the molecular aspects of gating and the interaction with effector proteins.

KW - Eukaryotic porin structure

KW - Intrinsic apoptotic pathway

KW - Ion-channel gating

KW - Membrane protein phylogeny

KW - Structural plasticity

KW - κ-barrel topology

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JO - Biological Chemistry

JF - Biological Chemistry

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ER -

Voltage-dependent anion channels: The wizard of the mitochondrial outer membrane

Abstract

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