Which drugs cause treatment-related problems? Analysis of 10,672 problems within the outpatient setting

Ghaith M. Al-Taani, Sayer I. Al-Azzam, Karem H. Alzoubi, Mamoon A. Aldeyab

Research output: Contribution to journalArticle

Abstract

Background: Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists’ efforts to patients that are at high risk for TRPs. Objectives: The present study aimed to identify medications most commonly associated with TRPs. Setting: Outpatient departments of five public and teaching hospitals in Jordan. Method: TRPs and drugs most commonly implicated with TRPs were assessed for patients recruited from outpatient clinics in five major hospitals in Jordan using a standardized and validated pharmaceutical care manual. Main outcome measure: Drugs associated with different types of TRPs. Results: Ultimately, 2,747 patients, with a total of 10,672 TRPs, were included in the study. The medication groups most commonly associated with TRPs were cardiovascular (53.0%), endocrine (18.1%), and gastrointestinal (7.7%) drugs. The most common specific drugs associated with TRPs from any category were atorvastatin (12.5%), metformin (8.5%), simvastatin (6.2%), and enal-april (5.9%). Cardiovascular medications were the most common drugs implicated with multiple subtypes of TRPs – most commonly, allergic reaction or undesirable effect (88.5%), drug product not available (87.3%), safety interaction issues (81.8%), a need for additional or more frequent monitoring (78.0%), and more effective drugs available (77.2%). Hypertension, diabetes mellitus, and dyslipidemia were the most common diseases associated with different subtypes of TRPs. Conclusion: The present study identified high-risk drugs for TRPs, which can be used as identification of targeting approach TRPs. Such an approach would improve care provided to patients and can inform health care policies.

Original languageEnglish
Pages (from-to)2273-2281
Number of pages9
JournalTherapeutics and Clinical Risk Management
Volume14
DOIs
Publication statusPublished - 16 Nov 2018
Externally publishedYes

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Drug therapy
Outpatients
drug
Health care
Drug products
cause
Pharmaceutical Preparations
Medical problems
Teaching
Therapeutics
Jordan
Monitoring
medication
Simvastatin
Metformin
health care
Delivery of Health Care
Gastrointestinal Agents
outpatient clinic
Pharmaceutical Services

Cite this

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title = "Which drugs cause treatment-related problems? Analysis of 10,672 problems within the outpatient setting",
abstract = "Background: Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists’ efforts to patients that are at high risk for TRPs. Objectives: The present study aimed to identify medications most commonly associated with TRPs. Setting: Outpatient departments of five public and teaching hospitals in Jordan. Method: TRPs and drugs most commonly implicated with TRPs were assessed for patients recruited from outpatient clinics in five major hospitals in Jordan using a standardized and validated pharmaceutical care manual. Main outcome measure: Drugs associated with different types of TRPs. Results: Ultimately, 2,747 patients, with a total of 10,672 TRPs, were included in the study. The medication groups most commonly associated with TRPs were cardiovascular (53.0{\%}), endocrine (18.1{\%}), and gastrointestinal (7.7{\%}) drugs. The most common specific drugs associated with TRPs from any category were atorvastatin (12.5{\%}), metformin (8.5{\%}), simvastatin (6.2{\%}), and enal-april (5.9{\%}). Cardiovascular medications were the most common drugs implicated with multiple subtypes of TRPs – most commonly, allergic reaction or undesirable effect (88.5{\%}), drug product not available (87.3{\%}), safety interaction issues (81.8{\%}), a need for additional or more frequent monitoring (78.0{\%}), and more effective drugs available (77.2{\%}). Hypertension, diabetes mellitus, and dyslipidemia were the most common diseases associated with different subtypes of TRPs. Conclusion: The present study identified high-risk drugs for TRPs, which can be used as identification of targeting approach TRPs. Such an approach would improve care provided to patients and can inform health care policies.",
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Which drugs cause treatment-related problems? Analysis of 10,672 problems within the outpatient setting. / Al-Taani, Ghaith M.; Al-Azzam, Sayer I.; Alzoubi, Karem H.; Aldeyab, Mamoon A.

In: Therapeutics and Clinical Risk Management, Vol. 14, 16.11.2018, p. 2273-2281.

Research output: Contribution to journalArticle

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AU - Al-Taani, Ghaith M.

AU - Al-Azzam, Sayer I.

AU - Alzoubi, Karem H.

AU - Aldeyab, Mamoon A.

PY - 2018/11/16

Y1 - 2018/11/16

N2 - Background: Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists’ efforts to patients that are at high risk for TRPs. Objectives: The present study aimed to identify medications most commonly associated with TRPs. Setting: Outpatient departments of five public and teaching hospitals in Jordan. Method: TRPs and drugs most commonly implicated with TRPs were assessed for patients recruited from outpatient clinics in five major hospitals in Jordan using a standardized and validated pharmaceutical care manual. Main outcome measure: Drugs associated with different types of TRPs. Results: Ultimately, 2,747 patients, with a total of 10,672 TRPs, were included in the study. The medication groups most commonly associated with TRPs were cardiovascular (53.0%), endocrine (18.1%), and gastrointestinal (7.7%) drugs. The most common specific drugs associated with TRPs from any category were atorvastatin (12.5%), metformin (8.5%), simvastatin (6.2%), and enal-april (5.9%). Cardiovascular medications were the most common drugs implicated with multiple subtypes of TRPs – most commonly, allergic reaction or undesirable effect (88.5%), drug product not available (87.3%), safety interaction issues (81.8%), a need for additional or more frequent monitoring (78.0%), and more effective drugs available (77.2%). Hypertension, diabetes mellitus, and dyslipidemia were the most common diseases associated with different subtypes of TRPs. Conclusion: The present study identified high-risk drugs for TRPs, which can be used as identification of targeting approach TRPs. Such an approach would improve care provided to patients and can inform health care policies.

AB - Background: Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists’ efforts to patients that are at high risk for TRPs. Objectives: The present study aimed to identify medications most commonly associated with TRPs. Setting: Outpatient departments of five public and teaching hospitals in Jordan. Method: TRPs and drugs most commonly implicated with TRPs were assessed for patients recruited from outpatient clinics in five major hospitals in Jordan using a standardized and validated pharmaceutical care manual. Main outcome measure: Drugs associated with different types of TRPs. Results: Ultimately, 2,747 patients, with a total of 10,672 TRPs, were included in the study. The medication groups most commonly associated with TRPs were cardiovascular (53.0%), endocrine (18.1%), and gastrointestinal (7.7%) drugs. The most common specific drugs associated with TRPs from any category were atorvastatin (12.5%), metformin (8.5%), simvastatin (6.2%), and enal-april (5.9%). Cardiovascular medications were the most common drugs implicated with multiple subtypes of TRPs – most commonly, allergic reaction or undesirable effect (88.5%), drug product not available (87.3%), safety interaction issues (81.8%), a need for additional or more frequent monitoring (78.0%), and more effective drugs available (77.2%). Hypertension, diabetes mellitus, and dyslipidemia were the most common diseases associated with different subtypes of TRPs. Conclusion: The present study identified high-risk drugs for TRPs, which can be used as identification of targeting approach TRPs. Such an approach would improve care provided to patients and can inform health care policies.

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