Biological Systems as Foundries for the Novel Manufacture of Nanotechnology via DNA Origami

  • Hannah McNiven

Student thesis: Doctoral Thesis

Abstract

Conventional methods for nanofabrication often struggle to create structures with high throughput at sub-50 nm sizes, where they have the ability to create small structures they are often high cost and low-throughput. DNA Origami has presented as a methodology which could tackle most issues encountered with conventional nanofabrication methods and allow for the high-throughput manufacture of sub-50 nm nanostructures at low cost. This work showcases the ability of DNA Origami to remain stable for prolonged periods of time under ambient conditions allowing its use outside of the strict conditions required for DNA to remain stable. This stability opens it up for a use in nanofabrication outside of the typical solution based conditions thought to be required for stability. The diverse applications of DNA Origami via functionalisation are highlighted through the fabrication of split ring resonators forming a low observable film and a metamaterial which responds to MWIR built upon a DNA Origami board via metallisation of the structure with copper. The beginnings of a CNT Nanoscale vacuum channel transistor structure fabricated on the DNA Origami surface further highlight the diverse range of manufacturing capabilities utilising DNA Origami. Together this work shows the capabilities of DNA Origami as a method for the novel manufacture of nanotechnology and has fabricated stable nanotechnologies with the capacity to be scaled up to larger manufacture levels as needed.
Date of Award23 May 2025
Original languageEnglish
SponsorsEngineering and Physical Sciences Research Council, Defence and Security Accelerator (DASA) & Air Force Office of Scientific Research
SupervisorRebecca Seviour (Main Supervisor) & Jarek Bryk (Co-Supervisor)

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